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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 515 - 518 (4page)
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Purpose: It is well known that testicular germ cell tumors arise with increased frequency in patients with cryptorchidism. In addition,intratubular germ cell neoplasia (ITGCN) is a precursor lesion to testicular germ cell tumor. Approximately 50% of patientswith ITGCN will develop an invasive of testicular germ cell tumors within 5 years. Therefore, we evaluated that the incidence ofITGCN in postpubertal cryptorchidism. Materials and Methods: Between January 2002 and August 2012, orchiectomy specimens from 31 postpubertalpatients (aged12 or over) with cryptorchid testis were reviewed. The specimens were evaluated for ITGCN using immunohistochemical stains ofplacental-like alkaline phosphatase and Oct 3/4 with routine hematoxylin-eosin stain. Additionally, the degree of spermatogenesiswas assessed using the Johnsen score. Results: Mean age was 34 years (range, 17 to 74 years) at surgery. All patients were diagnosed as unilateral cryptorchidism. Onepatient (3.2%) of 20-year-old had ITGCN in surgical specimen with all positive markers. Histological assessment of spermatogenesisshowed that mean Johnsen score was 3.42 (range, 1 to 9). Majority of patients (27 of 31) presented impaired spermatogenesis withlow Johnsen score lesser than 5. Conclusions: Considering the risk of malignancy and low spermatogenesis, we should perform immunohistochemical stains anddiscuss preventative orchiectomy for the postpubertal cryptorchidism.
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참고문헌 (20)
참고문헌 신청
Pourkeramati F / 2013 / Prevalence of intratubular germ cell neoplasia in cryptorchid testes of infertile men / Iran J Reprod Med 11:339~342
Cobellis G / 2014 / Spermatogenesis and cryptorchidism / Front Endocrinol 5:63
Urry RL / 1994 / The incidence of antisperm antibodies in infertility patients with a history of cryptorchidism / J Urol 151:381~383
Lifschitz-Mercer B / 2001 / Intratubular germ cell neoplasia: associated infertility and review of the diagnostic modalities / Int J Surg Pathol 9:93~98
Dieckmann KP / 1999 / Carcinoma in situ of the testis:review of biological and clinical features / Int J Cancer 83:815~822
Cobellis G / 2014 / Spermatogenesis and cryptorchidism / Front Endocrinol 5:63
Urry RL / 1994 / The incidence of antisperm antibodies in infertility patients with a history of cryptorchidism / J Urol 151:381~383
Lifschitz-Mercer B / 2001 / Intratubular germ cell neoplasia: associated infertility and review of the diagnostic modalities / Int J Surg Pathol 9:93~98
Dieckmann KP / 1999 / Carcinoma in situ of the testis:review of biological and clinical features / Int J Cancer 83:815~822
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