메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
M Hammad Ather (Aga Khan University) Syed M Nazim (Aga Khan University)
저널정보
대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.56 No.8
발행연도
2015.1
수록면
553 - 564 (12page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Nonmuscle invasive (NMI) urothelial cancer (UC) is associated with varied biological potential. It is characterized by frequent recurrenceand progression, which thus worsens the oncological outcome. Nearly three-quarters of NMI UCs recur within 5 years, whereashalf can progress during follow-up. Progression is particularly seen in T1 and carcinoma in situ (CIS). Undoubtedly, NMI UC is oneof the most expensive cancers to manage. The European Organisation for Research and Treatment of Cancer (EORTC) risk calculatoris a commonly used tool for assessing the recurrence and progression potential of a newly diagnosed cancer. The parameters usedin the assessment are tumor size and number, pathological stage and grade of the cancer, presence of CIS, and prior recurrencerate. The main advantages of the EORTC tool are its ease of use and the lack of need to run expensive molecular tests. However,reproducibility of pathologic stage and grade is modest, which is a concern to clinicians. Molecular markers have potential for predictingthe clinical outcome of NMI UC, given that clinico-pathologic variables are not sufficient for prediction of prognosis in anindividual. Significant work has been done in the past 2 decades in understanding the molecular biology of bladder cancer; however,the translational value of this knowledge remains poor. The role for molecular markers in predicting recurrence seems limitedbecause multifocal disease and incomplete treatment are probably more important for recurrence than the molecular features ofa resected tumor. Urinary markers have very limited value in prognostication of bladder cancer and are used (mainly as an adjunctto cytology) for detection and surveillance of urothelial cell cancer recurrence. Prediction of progression with molecular markersholds considerable promise. Nevertheless, the contemporary value of molecular markers over clinico-pathologic indexes is limited.

목차

등록된 정보가 없습니다.

참고문헌 (86)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0