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논문 기본 정보

자료유형
학술저널
저자정보
Tal Grenader (Shaare Zedek Medical Center) Linda Shavit (Shaare Zedek Medical Center)
저널정보
대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.56 No.12
발행연도
2015.1
수록면
791 - 795 (5page)

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Purpose: Although angiogenesis has been implicated in the promotion of renal cyst growth in autosomal dominant polycystic kidney disease, no studies have investigated the role of angiogenesis in the growth of simple renal cysts. The aim of current study was to investigate the effect of chemotherapy with the antivascular endothelial growth factor antibody bevacizumab on renal cyst development and growth in cancer patients. Materials and Methods: We retrospectively reviewed the medical records of 136 patients with a variety of cancers that were treated with bevacizumab-based chemotherapy for metastatic disease. The presence of and changes in renal cysts were evaluated by retrospective analysis of computed tomography scans performed for assessment of tumor response to bevacizumab-based therapy. Results: The median age of the patients was 64 years. Renal cysts were identified in 66 patients, in whom 33 (50%) had a single cyst and the rest had 2 or more cysts. The average dose of bevacizumab was 2.68 mg/kg per week. Median duration of treatment was 33 weeks. Average cyst size was 1.9±2.4 cm at the beginning of the study and the majority of the cysts (54 patients, 84%) did not change in size or shape during bevacizumab treatment. No patients were identified with new cysts. Cyst size changed in 10 patients (16%): an increase of 15% to 40% from the baseline size in 5 patients and a decrease in size of 10% to 70% in another 5 patients. The duration of bevacizumab therapy was significantly longer in the subgroup of patients with diminished or increased cyst size than in the patients with stable cyst size: 62 weeks versus 29 weeks, respectively (p=0.0002). Conclusions: Our data demonstrated that simple renal cysts were stable in size and number in the vast majority of cancer patients treated with bevacizumab.

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참고문헌 (28)

참고문헌 신청
Persson AB / 2011 / Vascular growth in health and disease / Front Mol Neurosci 4:14 google schola Wei W / 2006 / Evidence of angiogenesis and microvascular regression in autosomaldominant polycystic kidney disease kidneys: a corrosion cast study / Kidney Int 70:1261~1268 google schola Kidney Int / 2011 / Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease / Kidney Int 79:128~134 google schola Bello-Reuss E / 2001 / Angiogenesis in autosomal-dominant polycystic kidney disease / Kidney Int 60:37~45 google schola Los M / 1997 / Elevated ocular levels of vascular endothelial growth factor in patients with von Hippel-Lindau disease / Ann Oncol 8:1015~1022 google schola

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