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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 516 - 521 (6page)
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초록· 키워드
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Background and Objectives: Kawasaki disease is an acute systemic vasculitis of which pathogenesis suspected is caused by immunedysregulation. The goal of this study is to evaluate the activation pattern of T helper cell type 1 (Th1) and T helper cell type 2 (Th2) in patients withKawasaki disease. Subjects and Methods: Prospective study of 60 patients (male 36, female 24) with diagnosis of Kawasaki disease were enrolled. One hundred andeighty blood samples from these patients were collected according to the different clinical stages {before initial intravenous immunoglobulin (IVIG),5 days after initial IVIG, 2 months after initial IVIG}. The plasma level of Th1 cytokines; interferon-gamma (IFN-γ) & interleukin (IL)-2 and Th2cytokines; IL-4 & IL-10 were measured by enzyme-liked immunosorbent assay. Results: In all patients, the plasma level of Th1 cytokines (IFN-γ, IL-2) and Th2 cytokines (IL-4 and IL-10) were markedly elevated during the acutestage of Kawasaki disease. Since then, the plasma level of all these cytokines decreased significantly along with the process of clinical stages. Regardless of the existence of coronary artery lesion or no response to initial IVIG treatment, there were no significant differences between them. Conclusion: These data suggest that both Th1 and Th2 cells may be activated simultaneously during the acute stage of Kawasaki disease. Furtherstudies are therefore required to establish the difference of activation pattern of T helper cells between Kawasaki disease and other inflammatorydiseases.
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참고문헌 (24)
참고문헌 신청
Kawasaki T / 1967 / Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children / Arerugi 16:178~222
Takahashi K / 2014 / Update on etio and immunopathogenesis of Kawasaki disease / Curr Opin Rheumatol 26:31~36
Leung DY / 1990 / Immunologic aspects of Kawasaki syndrome / J Rheumatol 24:15~18
de Inocencio J / 1995 / The role of T cells in Kawasaki disease / Crit Rev Immunol 15:349~357
Jason J / 1997 / Immunoregulatory changes in Kawasaki disease / Clin Immunol Immunopathol 84:296~306
Takahashi K / 2014 / Update on etio and immunopathogenesis of Kawasaki disease / Curr Opin Rheumatol 26:31~36
Leung DY / 1990 / Immunologic aspects of Kawasaki syndrome / J Rheumatol 24:15~18
de Inocencio J / 1995 / The role of T cells in Kawasaki disease / Crit Rev Immunol 15:349~357
Jason J / 1997 / Immunoregulatory changes in Kawasaki disease / Clin Immunol Immunopathol 84:296~306
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