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자료유형
학술저널
저자정보
정종인 (삼성서울병원) 김수진 (성균관대학교) 홍상덕 (삼성서울병원) 정승규 (성균관대학교) 동헌종 (성균관대학교) 김효열 (성균관대학교)
저널정보
대한비과학회 Journal of Rhinology Journal of Rhinology Vol.22 No.2
발행연도
2015.1
수록면
75 - 81 (7page)

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Background: Obstructive sleep apnea (OSA) is characterized by repeated apnea, hypopnea, and micro-arousals during sleep. Many studies have described correlations between OSA and multiple systemic diseases, such as cardiovascular, cerebrovascular, and metabolic diseases. The aim of this study was to determine whether the compliance of continuous positive airway pressure (CPAP) affects the short-term systemic responses in OSA patients. Methods: Twenty-four newly diagnosed OSA patients were enrolled. All subjects used CPAP for 4 weeks. The subjects were divided into two groups according to the rate of using CPAP over 4 hours per night. Complete blood cell count, coagulation results, blood chemistry, lipid profiles, and pulmonary function results were evaluated at baseline, and were followed up after 4 weeks. Results: After CPAP treatment, WBC count, hemoglobin, hematocrit, albumin, AST, ALT, Cl, and peak expiratory flow rate (PEFR) were significantly changed in the higher compliance group (n=14), whereas platelet count and triglyceride levels were significantly changed in the lower compliance group (n=10). In multivariate analysis, the changes in WBC count, hemoglobin and hematocrit were statistically significant between the higher compliance and lower compliance groups (p=0.0056, 0.0016, and 0.0051). Conclusion: The compliance of CPAP affects the short-term systemic responses in OSA patient.

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