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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 118 - 124 (7page)
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초록· 키워드
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Objective: To evaluate the efficacy and tolerability of a neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy inpatients with locally advanced cervical carcinoma.
Methods: Patients with histologically confirmed locally advanced cervical carcinoma, aged ≥18 years, were treated withintravenous ifosfamide 5,000 mg/m2 and mesna 5,000 mg/m2, on day 1; intravenous paclitaxel 175 mg/m2 and cisplatin 75 mg/m2, on day 2; every 3 weeks for three cycles. Following chemotherapy, operable patients underwent radical hysterectomy andpelvic lymphadenectomy, and, if necessary, adjuvant radiotherapy.
Results: One hundred fifty-two patients with median age 53 years (range, 24 to 79 years), FIGO stage IIB in 126 (89%), weretreated with chemotherapy for median 3 cycles (range, 1 to 3). Treatment was delayed or withdrawn in 23 patients (15%). Onehundred thirty-nine patients (91%) underwent surgery. Postchemotherapy pathological complete response rate was 18% (25patients). Postoperative radiotherapy was administered in 100 patients (72%). The 5-year overall survival and progression-freesurvival were 87.3% (95% confidence interval [CI], 84.5 to 90.3) and 76.4% (95% CI, 73.5 to 79.5), respectively.
Conclusion: Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy was feasible and effective in the treatment oflocally advanced cervical carcinoma patients with older age and more advanced disease stage than reported in previous studies.
Hematological and renal toxicity could be carefully prevented.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
National Cancer Institute / Concurrent Chemoradiation for Cervical Cancer Clinical: Announcement
Eddy GL / 1995 / Neoadjuvant chemotherapy with vincristine and cisplatin followed by radical hysterectomy and pelvic lymphadenectomy for FIGO stage IB bulky cervical cancer: a Gynecologic Oncology Group pilot study / Gynecol Oncol 57:412~416
Leone B / 1996 / Ifosfamide and cisplatin as neoadjuvant chemotherapy for advanced cervical carcinoma / Am J Clin Oncol 19:132~135
Benedetti-Panici P / 1998 / Long-term survival following neoadjuvant chemotherapy and radical surgery in locally advanced cervical cancer / Eur J Cancer 34:341~346
Sananes C / 1998 / Neoadjuvant chemotherapy followed by radical hysterectomy and postoperative adjuvant chemotherapy in the treatment of carcinoma of the cervix uteri: long-term follow-up of a pilot study / Eur J Gynaecol Oncol 19:368~373
Eddy GL / 1995 / Neoadjuvant chemotherapy with vincristine and cisplatin followed by radical hysterectomy and pelvic lymphadenectomy for FIGO stage IB bulky cervical cancer: a Gynecologic Oncology Group pilot study / Gynecol Oncol 57:412~416
Leone B / 1996 / Ifosfamide and cisplatin as neoadjuvant chemotherapy for advanced cervical carcinoma / Am J Clin Oncol 19:132~135
Benedetti-Panici P / 1998 / Long-term survival following neoadjuvant chemotherapy and radical surgery in locally advanced cervical cancer / Eur J Cancer 34:341~346
Sananes C / 1998 / Neoadjuvant chemotherapy followed by radical hysterectomy and postoperative adjuvant chemotherapy in the treatment of carcinoma of the cervix uteri: long-term follow-up of a pilot study / Eur J Gynaecol Oncol 19:368~373
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