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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 322 - 331 (10page)
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The differentially expressed genes in the liver tissue of the marine medaka fish, Oryzias javanicus, were profiled using an oligo-microarray (EnviHaz Fish Array ver. 01) after the fish were exposed to 20 μg/L 4-nonylphenol (4-NP) for 12, 24, 48, or 72 h to determine the metabolic and physiological changes with exposure time. The transcriptomic changes were highly dynamic in the 4-NP-exposed fish in that among the 216 differentially expressed genes identified in all four exposed fish groups, 106 genes (49.1%) appeared after a specific exposure time. The differentially expressed genes were used to predict the changes that occurred in the metabolic pathways and processes in response to 4-NP exposure. Many physiological and metabolic changes were detected in the early phase of exposure. Significant vitellogenin expression and an estrogenic stimulus response were observed in the fish exposed to 4-NP for 48 h. These results extend our understanding of the biological responses to environmental chemicals at the molecular level and will allow the toxic effects of environmental chemicals, especially endocrine-disrupting chemicals, to be evaluated.
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참고문헌 (44)
참고문헌 신청
Jobling, S. / 2012 / State of the science of endocrine disrupting chemicals 2012 / United Nations Environmental Programme and the World Health Organization :260
Zhang, L. / 2013 / Effect of bisphenol A exposure during early development on glucose metabolism and adipokine expression in adolescent female rats / Mol. Cell. Toxicol 9:385~391
Lee, H.A. / 2013 / Longitudinal changes in offspring body weight, fat mass and sex hormone levels according to maternal bisphenol A exposure during gestation and lactation / Mol. Cell. Toxicol 9:285~293
Sager, D.B. / 1987 / Effect of early postnatal exposure to polychlorinated biphenyls (PCBs) on fertility in male rats / Bull. Environ. Contam. Toxicol 38:946~953
Jensen, A.A. / 2008 / Emerging endocrine disrupters:perfluoroalkylated substances / Int. J. Androl 31:161~169
Zhang, L. / 2013 / Effect of bisphenol A exposure during early development on glucose metabolism and adipokine expression in adolescent female rats / Mol. Cell. Toxicol 9:385~391
Lee, H.A. / 2013 / Longitudinal changes in offspring body weight, fat mass and sex hormone levels according to maternal bisphenol A exposure during gestation and lactation / Mol. Cell. Toxicol 9:285~293
Sager, D.B. / 1987 / Effect of early postnatal exposure to polychlorinated biphenyls (PCBs) on fertility in male rats / Bull. Environ. Contam. Toxicol 38:946~953
Jensen, A.A. / 2008 / Emerging endocrine disrupters:perfluoroalkylated substances / Int. J. Androl 31:161~169
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