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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 181 - 187 (7page)
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In recent years, perivascular stem cells (PVCs) have gained increasing attention as a promising source for regenerative medicine due to their greater differentiation potential compared to multipotent mesenchymal stem cells (MSCs). It has been reported that growth differentiation factor-5 (GDF-5) is involved in regulating proliferation and chondrogenic differentiation of MSCs. In this study, we investigated the effect of GDF-5 on the proliferation and chondrogenic differentiation of PVCs isolated from human umbilical cords. The supplementation of PVC cultures with GDF-5 (100 ng/mL) significantly enhanced their proliferative rate and augmented the size of pellets in micromass pellet cultures for chondrogenic induction. Although similar expression levels of chondrogenic-related genes were observed in chondrogenic pellets treated with GDF-5 compared to the pellets without GDF-5 treatment, these results indicate that supplementation of GDF-5 is able to acquire more chondrocytes when starting with equal amount of PVCs. Our study suggests that GDF-5 is an effective agent for the enhancement of PVC proliferation, thereby achieving a higher number of chondrocytes that are applicable in therapeutic doses for cartilage regeneration.
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참고문헌 (28)
참고문헌 신청
Harris JD / 2010 / Autologous chondrocyte implantation : a systematic review / J Bone Joint Surg Am 92:2220~2233
Hollander AP / 2010 / Stem cells and cartilage development : complexities of a simple tissue / Stem Cells 28:1992~1996
Zeifang F / 2010 / Autologous chondrocyte implantation using the original periosteum-cover technique versus matrix-associated autologous chondrocyte implantation : a randomized clinical trial / Am J Sports Med 38:924~933
Gong Y / 2010 / Microcavitary hydrogel-mediating phase transfer cell culture for cartilage tissue engineering / Tissue Eng Part A 16:3611~3622
Han EH / 2008 / Shaped, stratified, scaffold-free grafts for articular cartilage defects / Clin Orthop Relat Res 466:1912~1920
Hollander AP / 2010 / Stem cells and cartilage development : complexities of a simple tissue / Stem Cells 28:1992~1996
Zeifang F / 2010 / Autologous chondrocyte implantation using the original periosteum-cover technique versus matrix-associated autologous chondrocyte implantation : a randomized clinical trial / Am J Sports Med 38:924~933
Gong Y / 2010 / Microcavitary hydrogel-mediating phase transfer cell culture for cartilage tissue engineering / Tissue Eng Part A 16:3611~3622
Han EH / 2008 / Shaped, stratified, scaffold-free grafts for articular cartilage defects / Clin Orthop Relat Res 466:1912~1920
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