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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 131 - 139 (9page)
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Objectives: Columnar cell lesion (CCL), atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) may be premalignant lesion of mammary invasive carcinoma. A few recent investigators reported that the precursor lesions exhibited mucin production and they might be potential precursor lesion for mucinous carcinoma (mCA). This study aims to investigate the incidence and histopathologic characteristics of mucinous precursor lesions, including mucinous DCIS (mDCIS) and mucinous CCL (mCCL). Methods: We retrospectively analyzed invasive carcinomas with mucin. Cases were grouped into three subgroups: pure mCA, mixed mCA, and invasive carcinoma of no special type with mucin production (IC of NST-m). Precursor lesions were evaluated with PAS and alcian blue staining. Results: Total 27 cases of invasive carcinoma with mucin were analysed and classified as 18 pure mCA, 7 mixed mCA, and 2 IC of NST-m. mDCISs were found in 12 pure mCA, 4 mixed mCA and 2 IC of NST-m. mCCLs were found in 7 pure mCA and 2 mixed mCA. Majority of mucin was identified in both cytoplasm and ductal lumen, while some tumors exhibited only cytoplasmic mucin. We also observed three patterns of mDCIS classifiable by location of mucin and architecture of tumor cells. Conclusions: Cytoplasmic mucin suggested that mucinous feature of precursor lesions in the vicinity of mCA might not be a passive morphologic finding but be involved in development of mCA.
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참고문헌 (14)
참고문헌 신청
Abdel-Fatah TM / 2008 / Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family / Am J Surg Pathol 32:513~523
Simpson PT / 2005 / Columnar cell lesions of the breast : the missing link in breast cancer progression? A morphological and molecular analysis / Am J Surg Pathol 29:734~746
Sunil R / 2012 / WHO classification of tumours of the breast
Go EM / 2012 / Relationship between columnar cell changes and low-grade carcinoma in situ of the breast--a cytogenetic study / Hum Pathol 43:1924~1931
Moinfar F / 2000 / Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type ('clinging ductal carcinoma in situ'):a simulator of normal mammary epithelium / Cancer 88:2072~2081
Simpson PT / 2005 / Columnar cell lesions of the breast : the missing link in breast cancer progression? A morphological and molecular analysis / Am J Surg Pathol 29:734~746
Sunil R / 2012 / WHO classification of tumours of the breast
Go EM / 2012 / Relationship between columnar cell changes and low-grade carcinoma in situ of the breast--a cytogenetic study / Hum Pathol 43:1924~1931
Moinfar F / 2000 / Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type ('clinging ductal carcinoma in situ'):a simulator of normal mammary epithelium / Cancer 88:2072~2081
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