지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 270 - 276 (7page)
이용수
초록· 키워드
오류제보하기
Physiological agents trigger a signaling process called "inside-out signaling" and activated platelets promote adhesion, granule release, and conformational changes of glycoprotein IIb/IIIa (αIIb/β₃). Activated αIIb/β₃ interacts with fibrinogen and initiates a second signaling step called "external signaling". These two signaling pathways can cause hemostasis or thrombosis, and thrombosis is a possible medical problem in arterial and venous vessels, and platelet-mediated thrombosis is a major cause of cardiovascular disease (CVD). Therefore, modulating platelet activity is important for platelet-mediated thrombosis and cardiovascular disease. Esculetin is a coumarin-based physiologically active 6,7-dihydroxy derivative known to have pharmacological activity against obesity, diabetes, renal failure and CVD. Although some studies have confirmed the effects of esculetin in human platelet activation and experimental mouse models, it is not clear how esculetin has antiplatelet and antithrombotic effects. We confirmed the effect and mechanism of action of escultein on human platelets induced by collagen. As a result, esculetin decreased Ca<SUP>2+</SUP> recruitment through upregulation of inositol 1, 4, 5-triphosphate receptor. In addition, esculetin upregulates cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-dependent pathways and inhibits fibrinogen binding and thrombus contraction. Our results demonstrate the antiplatelet effect and antithrombotic effect of esculetin in human platelets. Therefore, we suggest that esculetin could be a potential phytochemical for the prevention of thrombus-mediated CVD.
목차
서론
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (20)
참고문헌 신청
Cavallini L / 1996 / Prostacyclin and sodium nitroprusside inhibit the activity of the platelet inositol 1, 4, 5-trisphosphate receptor and promote its phosphorylation / J Biol Chem 271:5545~5551
Chen H / 2003 / Reciprocal signaling by integrin and nonintegrin receptors during collagen activation of platelets / Mol Cell Biol 23:4764~4777
Grynkiewicz G / 1985 / A new generation of Ca2+indicators with greatly improved fluorescence properties / J Biol Chem 260:3440~3450
Farndale RW / 2006 / Collagen-induced platelet activation / Blood Cell Mol Dis 36:162~165
Hsia CW / 2019 / Esculetin, a Coumarin Derivative, Prevents Thrombosis: Inhibitory Signaling on PLCγ2-PKC-AKT Activation in Human Platelets / Int J Mol Sci 20:2731
Chen H / 2003 / Reciprocal signaling by integrin and nonintegrin receptors during collagen activation of platelets / Mol Cell Biol 23:4764~4777
Grynkiewicz G / 1985 / A new generation of Ca2+indicators with greatly improved fluorescence properties / J Biol Chem 260:3440~3450
Farndale RW / 2006 / Collagen-induced platelet activation / Blood Cell Mol Dis 36:162~165
Hsia CW / 2019 / Esculetin, a Coumarin Derivative, Prevents Thrombosis: Inhibitory Signaling on PLCγ2-PKC-AKT Activation in Human Platelets / Int J Mol Sci 20:2731
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UCI(KEPA) : I410-ECN-0101-2022-510-000141763