지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 368 - 375 (8page)
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초록· 키워드
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Objective: Gout is one of the most common forms of inflammatory arthritides among men, which is caused primarily by chronic hyperuricemia. Although pharmacological therapy is the mainstay treatment to manage gout, limiting the consumption of dietary purine is also important. Several epidemiological studies have reported that alcohol consumption is closely related to hyperuricemia and gout. The objective of this study was to determine the purine content in common Korean alcoholic beverages using high performance liquid chromatography (HPLC) to provide a dietary guideline for those with hyperuricemia or gout.
Methods: Thirty-five alcoholic beverages were analyzed. Blindly labeled samples of each alcoholic beverage were degassed and frozen. The sample preparation prior to HPLC followed the methods of Japanese researchers. HPLC was performed to analyze adenine, guanine, hypoxanthine, and xanthine content in the alcoholic beverages.
Results: The standard curves were linear for all purines. Purine contents were as follows: beer (42.26∼146.39 μmol/L, n=12), medicinal wine (8.2 and 40.41 μmol/L, n=2), rice wine (13.19 μmol/L), Makgeolri (11.71 and 24.72 μmol/L, n=2), red wine (0, 6.03, and 17.9 μmol/L, n=3). No purines were found in fruit wine (n=2), Kaoliang (n=1), white wine (n=1), or distilled alcoholic beverages, such as soju (n=10) or whiskey (n=1).
Conclusion: Among popular Korean alcoholic beverages, beer contained a considerable amount of purines, whereas distilled alcoholic beverages did not. Patients with either gout or hyperuricemia should avoid alcoholic beverages, especially those containing large amounts of purines.
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참고문헌 (21)
참고문헌 신청
Richette P / 2010 / Gout / Lancet 375:318~328
Saag KG / 2006 / Epidemiology, risk factors, and lifestyle modifications for gout / Arthritis Res Ther 8(Suppl 1):S2
Bieber JD / 2004 / Gout: on the brink of novel therapeutic options for an ancient disease / Arthritis Rheum 50:2400~2414
Neogi T / 2006 / Frequency and predictors of inappropriate management of recurrent gout attacks in a longitudinal study / J Rheumatol 33:104~109
Zhang W / 2006 / EULAR evidence based recommendations for gout. Part II: management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) / Ann Rheum Dis 65:1312~1324
Saag KG / 2006 / Epidemiology, risk factors, and lifestyle modifications for gout / Arthritis Res Ther 8(Suppl 1):S2
Bieber JD / 2004 / Gout: on the brink of novel therapeutic options for an ancient disease / Arthritis Rheum 50:2400~2414
Neogi T / 2006 / Frequency and predictors of inappropriate management of recurrent gout attacks in a longitudinal study / J Rheumatol 33:104~109
Zhang W / 2006 / EULAR evidence based recommendations for gout. Part II: management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) / Ann Rheum Dis 65:1312~1324
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