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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 75 - 78 (4page)
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Abciximab (ReoPro) is an extremely potent inhibitor of the glycoprotein IIb/IIIa receptor. Its main application is in the maintenance of coronary flow after suboptimal coronary intervention. Complications associated with this drug include bleeding and severe thrombocytopenia. We report a case of severe thrombocytopenia secondary to abciximab therapy for percutaneous coronary intervention in a 65-year-old woman suffering from an acute myocardial infarction. Her platelet count dropped to 1,000/mm3 7 hours after abciximab administration and improved with transfusion of 12 units of platelet concentrate the following day. The patient was diagnosed through measurement of heparin-dependent antibodies and readministration of heparin.
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참고문헌 (20)
참고문헌 신청
Coller BS / 1995 / Blockade of platelet GPIIb/IIIa receptors as an antithrombotic strategy / Circulation 92:2373~2380
Topol EJ / 1999 / Platelet GP IIb-IIIa blockers / Lancet 353:227~231
Kereiakes DJ / 2000 / Clinical correlates and course of thrombocytopenia during percutaneous coronary intervention in the era of abciximab platelet glycoprotein IIb/IIIa blockade / Am Heart J 140:74~80
Berkowitz SD / 1997 / Acute profound thrombocytopenia after c7E3 Fab (abciximab) therapy / Circulation 95:809~813
Aster RH / 2006 / Thrombocytopenia associated with the use of GPIIb/IIIa inhibitors: position paper of the ISTH working group on thrombocytopenia and GPIIb/IIIa inhibitors / J Thromb Haemost 4:678~679
Topol EJ / 1999 / Platelet GP IIb-IIIa blockers / Lancet 353:227~231
Kereiakes DJ / 2000 / Clinical correlates and course of thrombocytopenia during percutaneous coronary intervention in the era of abciximab platelet glycoprotein IIb/IIIa blockade / Am Heart J 140:74~80
Berkowitz SD / 1997 / Acute profound thrombocytopenia after c7E3 Fab (abciximab) therapy / Circulation 95:809~813
Aster RH / 2006 / Thrombocytopenia associated with the use of GPIIb/IIIa inhibitors: position paper of the ISTH working group on thrombocytopenia and GPIIb/IIIa inhibitors / J Thromb Haemost 4:678~679
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