인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록·키워드
Background: Differently from a theory, the test results of anti-extractable nuclear antigen antibody (ENA Ab) are sometimes positive when those of antinuclear antibody are negative in the same patient. We performed the association analysis between the result of ANA and that of R060 and Ro52 ENA Abs which are prevalently identified in the laboratory practice. Methods: From January 2006 to June 2007, a total of 133 patients’ test results of ANA by indirect immunofluorescence assay (IIFA) and 13 ENA Abs by line immunoassay (LIA) were analyzed. The patients were divided into 3 groups depending on the results of Ro antibodies: 1) Ro60 (+)-Ro52 (+), 2) Ro60 (+)-Ro52 (-), 3) Ro60 (-)-Ro52 (+). The associations between the results of IIFA and those of LIA in between the groups were analyzed. The associations between the results of IIFA and those of LIA and the prevalence of ENA Abs were analyzed in the ENA (+) group. The prevalence of ENA Abs in the IIFA (-)-LIA (+) group was analyzed. The distributions of ENA Abs identified in the same patient were analyzed in LIA (+), IIFA (+)-LIA (+), and IIFA (-)-LIA (+) groups. Results: There were no statistical differences between the results of ANA and those of ENA Abs in between the groups, but significant difference was suspected between the Ro60 (+)-Ro52 (+) and the Ro60 (-)-Ro52 (+) groups (p=0.052). The prevalence of Ro60 and Ro52 were high among 13 ENA Abs identified (18.8% and 24% respectively). Statistically significant association between the results of ANAs and those of Ro60 was observed (p=0.005). The prevalence of Ro52 was highest in the IIFA (-)-LIA (+) group (28.6%). The numbers of ENA Abs identified in the same patient decreased in the IIFA (-)-LIA (+) group. Conclusion: When the autoimmune diseases associated with Ro52 autoantibody are suspected, an ENA profile test should be performed regardless of the ANA results.
본문·목차
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오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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