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논문 기본 정보

자료유형
학술저널
저자정보
(Kyung Hee University) (Kyung Hee University) (Kyung Hee University) (Kyung Hee University) (Konkuk University) (Kyung Hee University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.46 No.3
발행연도
수록면
337 - 347 (11page)

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초록· 키워드

Coronavirus disease 2019 (COVID-19) is currently a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 are directly associated with hyper-activation of innate immune response that excessively produce pro-inflammatory cytokines and induce cytokine storm, leading to multi-organ-failure and significant morbidity/mortality. Currently, several antiviral drugs such as Paxlovid (nirmatrelvir and ritonavir) and molnupiravir are authorized to treat mild to moderate COVID-19, however, there are still no drugs that can specifically fight against challenges of SARS-CoV-2 variants. Panax ginseng, a medicinal plant widely used for treating various conditions, might be appropriate for this need due to its anti-inflammatory/cytokine/viral activities, fewer side effects, and cost efficiency. To review Panax ginseng and its pharmacologically active-ingredients as potential phytopharmaceuticals for treating cytokine storm of COVID-19, articles that reporting its positive effects on the cytokine production were searched from academic databases. Experimental/clinical evidences for the effectiveness of Panax ginseng and its active-ingredients in preventing or mitigating cytokine storm, especially for the cascade of cytokine storm, suggest that they might be beneficial as an adjunct treatment for cytokine storm of COVID-19. This review may provide a new approach to discover specific medications using Panax ginseng to control cytokine storm of COVID-19.
#Coronavirus disease 2019 #SARS-CoV-2 #Cytokine storm #Panax ginseng #Therapeutic strategies
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목차

  1. ABSTRACT
  2. 1. Introduction
  3. 2. Methods
  4. 3. Pathogenesis of COVID-19
  5. 4. Immunopathogenesis and cytokine storm of COVID-19
  6. 5. Panax ginseng as an adjuvant treatment forimmunopathogenesis and cytokine storm of COVID-19
  7. 6. Conclusions
  8. References

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