지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Evidence regarding the efficacy of Ginkgo biloba extract on cognitive function has been contentious. This study evaluated the effective period of G. biloba intake to improve cognition in the elderly. PubMed, EMBASE, Cochrane, Web of Science, and PsycArticles databases were searched for short-listing relevant studies. Twenty-five studies fulfilled the inclusion criteria. Cognitive efficacy was assessed based on the duration of intervention. G. biloba intake for 3-6 months statistically significantly affected cognitive function (SMD= −0.21; 95% CI −0.39, −0.03; p=0.02). However, the improvement in activities of daily living (ADLs) was not statistically significant. Thus, G. biloba intake for more than three months improves cognition in the elderly people with cognitive impairment and AD dementia without any safety risk. Intake for up to six months does not improve ADLs significantly in mild to moderate dementia patients.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (38)
참고문헌 신청
Amieva H, Meillon C, Helmer C, Barberger-Gateau P, Dartigues JF. Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study. PLoS One. 8: e52755 (2013)
Băjenaru O, Prada G, Antochi F, Jianu C, Tudose C, Cuciureanu A, Docu AA, Perrot V, Avram M, Tiu C. Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment. CNS Neurol. Disord. Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders). 20: 378-384 (2021)
Birks J, Evans JG. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst. Rev. (2009)
Brautigam MRH, Blommaert FA, Verleye G, Castermans J, Steur EJ, Kleijnen J. Treatment of age-related memory complaints with Ginkgo biloba extract: a randomized double-blind placebo-controlled study. Phytomedicine. 5: 425-434 (1998)
Cockle SM, Kimber S, Hindmarch I. The effects of Ginkgo biloba extract (LI 1370) supplementation on activities of daily living in free-living older volunteers: a questionnaire survey. Hum. Psychopharmacol. 15: 227-235 (2000)
Băjenaru O, Prada G, Antochi F, Jianu C, Tudose C, Cuciureanu A, Docu AA, Perrot V, Avram M, Tiu C. Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment. CNS Neurol. Disord. Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders). 20: 378-384 (2021)
Birks J, Evans JG. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst. Rev. (2009)
Brautigam MRH, Blommaert FA, Verleye G, Castermans J, Steur EJ, Kleijnen J. Treatment of age-related memory complaints with Ginkgo biloba extract: a randomized double-blind placebo-controlled study. Phytomedicine. 5: 425-434 (1998)
Cockle SM, Kimber S, Hindmarch I. The effects of Ginkgo biloba extract (LI 1370) supplementation on activities of daily living in free-living older volunteers: a questionnaire survey. Hum. Psychopharmacol. 15: 227-235 (2000)
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UCI(KEPA) : I410-ECN-0101-2022-594-001692629