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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.3
- 수록면
- 60 - 69 (10page)
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초록· 키워드
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The worldwide prevalence and severity of allergic diseases including atopic and contact dermatitis has increased dramatically over the past decade, especially in developed countries. Mast cells are important effector cells in allergic reactions. The purpose of this study was undertaken to investigate the anti-allergic and anti-pruritic effects of Diospyros lotus leaf extract (DLE). DLE was prepared by extracting with distilled water. In the present study, we investigated the effect of DLE on the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1α) and histamine in rat peritoneal mast cells (RPMCs), and on the skin lesion, leukocyte infiltration and scratching behavior in mice. Phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 significantly increased TNF-α and IL-1β production compared with media control. However, TNF-α and IL-6 production increased by PMA plus A23187 treatment were significantly inhibited by DLE in a dose-dependent manner. DLE also inhibited the histamine release from RPMCs stimulated by compound 48/80, which promotes histamine release. Moreover, DLE administration had an inhibitory effects on the scratching behavior induced by pruritogen (compound 48/80, histamine) in ICR mice. Furthermore, DLE inhibited the skin lesions, inflammatory and mast cells in hairless mice sensitized by 2,4-dinitrofluorobenzene (DNFB). DLE administration reduced the IL-4 and IgE production induced by DNFB sensitization in hairless mice. These results suggest that DLE has a potential use as a herb medicine for treatment against allergy and pruritusrelated disease.
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참고문헌 (25)
참고문헌 신청
Kay, A. B. / 2009 / Overview of allergy and allergic diseases: with a view to the future / Br. Med. Bull 56:843~864
Warner, J. O. / 2006 / Allergy practice worldwide: a report by the World Allergy Organization Specialty and Training Council / Int. Arch. Allergy Immunol 139:166~174
Takai, T. / 2011 / Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases / Allergol. Int 60:25~35
Spergel, J. M. / 2010 / Epidemiology of atopic dermatitis and atopic march in children / Immunol. Allergy Clin. North Am 30:269~280
Hon, K. L. / 2012 / Research statistics in atopic eczema: what disease is this? / Ital. J. Pediatr 38:26
Warner, J. O. / 2006 / Allergy practice worldwide: a report by the World Allergy Organization Specialty and Training Council / Int. Arch. Allergy Immunol 139:166~174
Takai, T. / 2011 / Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases / Allergol. Int 60:25~35
Spergel, J. M. / 2010 / Epidemiology of atopic dermatitis and atopic march in children / Immunol. Allergy Clin. North Am 30:269~280
Hon, K. L. / 2012 / Research statistics in atopic eczema: what disease is this? / Ital. J. Pediatr 38:26
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