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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 269 - 274 (6page)
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이 논문의 연구 히스토리 (5)
2016
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In this study, we investigated the anticancer effect of rice bran extract in HL-60 human promyelocytic leukemia cells. The extract of rice bran inhibited the proliferation of HL-60 cells. When treated with the rice bran extract, we could observe the apoptotic characteristics such as apoptotic bodies and the increase of sub-G1 hypodiploid cell population, increase of Bax level, decrease of Bcl-2 expression, cleavage of procaspase-3, cleavage of procaspase-9 and cleavage of poly(ADPribose) polymerase(PARP) in HL-60 cells. Furthermore, the apoptosis induction of HL-60 cells treated with the rice bran extract was also accompanied by the inactivation of mitogen-activated protein kinases (MAPK) such as ERK1/2 MAPK and p38 MAPK. In addition, the rice bran extract induced the down-regulation of c-myc. These data suggested that the rice bran extract could induce the apoptosis via the inactivation of ERK1/2 MAPK and p38 MAPK, and the down-regulation of c-myc in HL- 60 acute pomyelocytic leukemia cells. The results support that the rice bran extract might have potential for the treatment of acute promyelocytic leukemia.
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참고문헌 (23)
참고문헌 신청
최현임 / 2010 / 일반쌀겨와 발효쌀겨의 영양성분에 관한 연구 / 한국식품영양학회지 23(1):1~7
Bill Roschek Jr. / 2009 / Pro-Inflammatory Enzymes, Cyclooxygenase 1, Cyclooxygenase 2, and 5-Lipooxygenase, Inhibited by Stabilized Rice Bran Extracts / Journal of Medicinal Food 12(3):615~623
Xu, Z. / 2001 / Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2'-azobis(2-methylpropionamidine) dihydrochloride / Journal of Agricultural and Food Chemistry 49:2077~2081
Ha, H. / 2011 / α-Tocotrienol inhibits osteoclastic bone resorption by suppressing RANKL expression and signaling and bone resorbing activity / Biochem. Biophys. Res. Commun 406:546~551
Lai, M. H. / 2012 / Effects of rice bran oil on the blood lipids profiles and insulin resistance in type 2 diabetes patients / Journal of clinical biochemistry and nutrition 51:15~18
Bill Roschek Jr. / 2009 / Pro-Inflammatory Enzymes, Cyclooxygenase 1, Cyclooxygenase 2, and 5-Lipooxygenase, Inhibited by Stabilized Rice Bran Extracts / Journal of Medicinal Food 12(3):615~623
Xu, Z. / 2001 / Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2'-azobis(2-methylpropionamidine) dihydrochloride / Journal of Agricultural and Food Chemistry 49:2077~2081
Ha, H. / 2011 / α-Tocotrienol inhibits osteoclastic bone resorption by suppressing RANKL expression and signaling and bone resorbing activity / Biochem. Biophys. Res. Commun 406:546~551
Lai, M. H. / 2012 / Effects of rice bran oil on the blood lipids profiles and insulin resistance in type 2 diabetes patients / Journal of clinical biochemistry and nutrition 51:15~18
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UCI(KEPA) : I410-ECN-0101-2023-518-000068014