인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 247 - 253 (7page)
이용수
초록· 키워드
The antitumor activity of crude saponin mixture obtained from Luffa tuberosa (Roxb.) (Fam; Cucurbitaceae) hairy roots (CSLT) in mice transplanted with Ehrlich ascites carcinoma (EAC) was investigated. The EAC-bearing mice receiving 150 and 300 ug/kg body weight, (i.p) of CSLT have shown a dose dependent elevation in tumor-free survival and a highest number of survivors were observed after administration of CSLT (300 ug/kg), which was considered as an optimum dose for its antineoplastic action. The mean survival time (MST) for this dose was approximately 47.1 ± 0.74 d, when compared with 19.0 ± 0.36 d of untreated control. Administration of 300 ug/kg CSLT resulted in 130% long-term increased survival time. The measurement of body weight, tumor volume, packed cell volume, viable and non-viable count indicated the efficacy of CSLT in tumor-bearing mice, there was a significant recovery in hematological profiles, and there was depletion in lipid peroxidation levels, and the antioxidant enzyme activities such as GSH, SOD and CAT were restored to near the normal levels. The CSLT was found to be devoid of conspicuous short-term toxicity in the mice when animals were intraperitoneally injected with 250, 500, 750 and 1000 ug/kg bodyweight. The treated mice showed conspicuous toxic symptoms only at a dose of 1500 ug/kg. Mortality of the animals was monitored up to 14 d post drug treatment, 1/7th of the LD50 dose has been considered for the optimal antineoplastic activity.
#antineoplastic activity
#antioxidant
#hematological profiles
#Luffa tuberosa (Roxb.) Ehrlich ascites carcinoma
상세정보 수정요청해당 페이지 내 제목·저자·목차·페이지정보가 잘못된 경우 알려주세요!
목차
등록된 정보가 없습니다.
참고문헌
참고문헌 신청최근 본 자료
UCI(KEPA) : I410-ECN-0101-2023-518-000066141
