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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 115 - 121 (7page)
- DOI
- 10.20307/nps.2021.27.2.115
이용수
초록· 키워드
오류제보하기
Lentinus edodes contains functional metabolites such as polysaccharopeptides, lectins, and secondary metabolites. Fermented soybean paste is representative fermented materials in Korea, and is gradually increasing due to various biological activities. In the present study, ethanol extracts of fermented products with/without L. edodes were designated as SPL and SP, and prepared to develop safer and therapeutic functional foods with antioxidant and anti-inflammatory activities for treatment of inflammatory disorders. SP and SPL extracts exhibited antioxidant effects via inhibiting radical activities. Inflammatory mediators, nitric oxide (NO), prostaglandin E₂ (PGE₂), interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, and inducible nitric oxide synthase (iNOS) production and nuclear factor-kappa B (NF-ĸB) activation were down-regulated by two extracts. SPL extract more strongly enhanced the antioxidant and anti-inflammatory activities than SP extract. Its’ activities shown more longer fermentation period and more strong inhibitory effects. Taken together, our results suggested that fermented product with medicinal plant has synergic effect and SPL can be a potential candidate for treatment of inflammatory bowel diseases.
목차
Abstract
Introduction
Experimental
Results and discussion
References
참고문헌 (27)
참고문헌 신청
He, Y. / 2015 / Molecules 20:9183~9213
김경미 / 2015 / Intestinal anti-inflammatory activity of Sasa quelpaertensis leaf extract by suppressing lipopolysaccharide-stimulated inflammatory mediators in intestinal epithelial Caco-2 cells co-cultured with RAW 264.7 macrophage cells / Nutrition Research and Practice 9(1):3~10
German, A. J. / 2001 / J. Vet. Intern. Med. 15:14~25
Bode, H. / 1998 / Cytokine 10:457~465
Jeong, D. E. / 2020 / Int. Immunopharmacol. 86:106576
김경미 / 2015 / Intestinal anti-inflammatory activity of Sasa quelpaertensis leaf extract by suppressing lipopolysaccharide-stimulated inflammatory mediators in intestinal epithelial Caco-2 cells co-cultured with RAW 264.7 macrophage cells / Nutrition Research and Practice 9(1):3~10
German, A. J. / 2001 / J. Vet. Intern. Med. 15:14~25
Bode, H. / 1998 / Cytokine 10:457~465
Jeong, D. E. / 2020 / Int. Immunopharmacol. 86:106576
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