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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.6
- 수록면
- 109 - 117 (9page)
- DOI
- 10.20307/nps.2020.26.2.109
이용수
초록· 키워드
오류제보하기
The canonical Wnt/β-catenin signaling pathways play an important role in the embryonic development, cell proliferation, differentiation, and adhesion. Therefore, the abnormal activation and repression have been associated with uncontrolled homeostasis in human tissues. In particular, the activation of Wnt signaling is highly correlated with a diverse of diseases including cancer. On this regard, a strategy for targeting Wnt/β-catenin signaling has been employed in the discovery and development of antitumor agents. Herein, the evolution of Wnt signaling and the Wnt inhibitors derived from natural products were briefly summarized in the drug discovery of anticancer agents.
목차
Abstract
Introduction
Wnt signal transduction pathways
Wnt in colon cancer
Wnt in other cancers
Examples of natural products targeting Wnt signaling pathway
Structure-activity relationship studies of natural product derivatives targeting Wnt signaling pathway
Future directions
References
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