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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.3
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- 41 - 48 (8page)
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This study was conducted to evaluate the effects of Padina arborescens and 1–O–myristoyl–2–O–oleoyl–3–O–(α–D–glucopyranosyl)–glycerol(MOGG), its active component, on the prevention of hair loss. The P. arborescens extract and MOGG inhibited the activity of 5α-reductase, which converts testosterone to dihydrotestosterone(DHT), a main cause of androgenetic alopecia. When immortalized rat vibrissa dermal papilla cells were treated with MOGG, the proliferation of dermal papilla cells significantly increased. In addition, we found that the P. arborescens extract and MOGG could open the K<SUB>ATP</SUB> channel, which may contribute to increase hair growth. Furthermore, MOGG promoted PGE₂ production in HaCaT cells. The results suggest that MOGG from the P. arborescens extract has the potential to treat alopecia via 5α-reductase inhibition, the proliferation of dermal papilla, the opening of the K<SUB>ATP</SUB> channel and/or increase of PGE₂ production.
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Abstract
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참고문헌 (37)
참고문헌 신청
Price, V. H. / 1999 / Treatment of hair loss / N. Engl. J. Med 341:964~973
Ellis, J. A. / 2002 / Androgenetic alopecia : pathogenesis and potential for therapy / Expert. Rev. Mol. Med 4:1~11
Elliott, K. / 1999 / Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number : implications for the control of hair follicle size and androgen responses / J. Invest. Dermatol 113:873~877
Kaufman, K. D. / 2002 / Androgens and alopecia / Mol. Cell Endocrinol 198:89~95
Mecklenburg, L. / 2000 / Active hair growth(anagen)is associated with angiogenesis / J. Invest. Dermatol 114:909~916
Ellis, J. A. / 2002 / Androgenetic alopecia : pathogenesis and potential for therapy / Expert. Rev. Mol. Med 4:1~11
Elliott, K. / 1999 / Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number : implications for the control of hair follicle size and androgen responses / J. Invest. Dermatol 113:873~877
Kaufman, K. D. / 2002 / Androgens and alopecia / Mol. Cell Endocrinol 198:89~95
Mecklenburg, L. / 2000 / Active hair growth(anagen)is associated with angiogenesis / J. Invest. Dermatol 114:909~916
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