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논문 기본 정보

자료유형
학술저널
저자정보
Dong-Hyuk Choi (Gwangju Institute of Science and Technology) Sungchul Kim (Gwangju Institute of Science and Technology) Teo Jeon Shin (Seoul National University) Seonghyun Kim (Gwangju Institute of Science and Technology) Jae Gwan Kim (Gwangju Institute of Science and Technology)
저널정보
한국광학회 Current Optics and Photonics Current Optics and Photonics Vol.6 No.5
발행연도
2022.10
수록면
489 - 496 (8page)

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초록· 키워드

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Our previous study on monitoring cerebral oxygenation with a variation of isoflurane concentration in a rat model showed that near-infrared spectroscopy (NIRS) signals have potential as a new depth of anesthesia (DOA) index. However, that study obtained results from the brain in a completely invasive way, which is inappropriate for clinical application. Therefore, in this follow-up study, it was investigated whether the NIRS signals measured in a minimally invasive model including the skull and cerebrospinal fluid layer (CSFL) are similar to the previous study used as a gold standard. The experimental method was the same as the previous study, and only the subject model was different. We continuously collected NIRS signals before, during, and after isoflurane anesthesia. The isoflurane concentration started at 2.5% (v/v) and decreased to 1.0% by 0.5% every 5 min. The results showed a positive linear correlation between isoflurane concentration and ratio of reflectance intensity (RRI) increase, which is based on NIRS signals. This indicates that the quality of NIRS signals passed through the skull and CSFL in the minimally invasive model is as good as the signal obtained directly from the brain. Therefore, we believe that the results of this study can be easily applied to clinics as a potential indicator to monitor DOA.

목차

Ⅰ. INTRODUCTION
Ⅱ. METHOD
Ⅲ. RESULTS
Ⅳ. DISCUSSIONS AND CONCLUSION
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