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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 160 - 169 (10page)
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초록· 키워드
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Helicobacter pylori (H. pylori) was defined as a Class 1 pathogenic carcinogen by WHO causing chronic inflammation in the stomach, thereby increasing the risk of gastric cancer. Various virulence factors are involved in the mechanism of gastric cancer caused by H. pylori infection. These virulence factors usually show different expression levels depending on the environment of H. pylori, which can affect the risk of gastric cancer. In this study, the differences in the expression levels of major virulence factors of H. pylori depending on the environment were investigated by comparing expression levels of H. pylori cultured with AGS or alone. As a result, there was no difference in the expression of adhesins of alpA, sabA, and babA even after co-culture with AGS cells. In addition, the co-culture environment did not induce a difference in the expression levels of flaA and ureB. On the other hand, H. pylori co-cultured with AGS cells showed low expression levels of cagA, groEL, and oipA and high expression of vacA compared to H. pylori cultured alone. Our results suggest that not only the presence or absence of virulence factor genes but also differences in expression levels should be considered when evaluating the risk of gastric cancer after H. pylori infection based on the virulence factors.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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