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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.9
- 수록면
- 153 - 161 (9page)
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초록· 키워드
오류제보하기
Cotoneaster mongolicus Pojark. (CM), in the family Rosaceae is an endemic plant to the Mongolian region (its name: Монгол чаргай). In Mongolia, Cotoneaster species as a crude drug is mainly used for inflammatory diseases, diarrhea, and stomach indigestion. In this study, we evaluated the gastro-protective activity underlying mechanism of CM. For in vivo experiments, mice were divided into 5 groups; normal mice (Normal), gastritis mice (Control), gastritis mice treated with sucralfate 10 mg/kg (SC), gastritis mice treated with CM 100 mg/kg (CML), gastritis mice treated with CM 200 mg/kg (CMH). Gastritis was provoked by HCl/ethanol (60% ethanol in 150 mM HCl). After oral administration of each drug, HCl/ethanol was orally administered 90 mins later to induce gastritis. CM alleviated the damage to the gastric mucosa caused. As a result of confirming the expression of protein in gastric tissue through western blot, CM significantly reduced the expression of NF-κB activated due to gastritis. Also, it significantly modulated the Nrf2-Keap1 pathway. These results indicate that CM not only inhibits the nuclear metastasis of NF-κB but also modulates the Nrf2-Keap1 pathway to relieve inflammation of the gastric mucosa.
목차
Abstract
재료 및 방법
결과
고찰
결론
인용문헌
참고문헌 (27)
참고문헌 신청
Jainu, M. and Devi, C. S. (2006) Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation. J. Ethnopharmacol. 104: 156-163.
Yeo, D., Hwang, S. J., Song, Y. S. and Lee, H. J. (2021) Humulene inhibits acute gastric mucosal injury by enhancing mucosal integrity. Antioxidants 10: 761.
Nomura, A., Stemmermann, G. N., Chyou, P. H., Perez-Perez, G. I. and Blaser, M. J. (1994) Helicobacter pylori infection and the risk for duodenal and gastric ulceration. Ann. Intern. Med. 120: 977-981.
Mousa, A. M., El-Sammad, N. M., Hassan, S. K., Madboli, A. E. N. A., Hashim, A. N., Moustafa, E. S., Bakry, S. M. and Elsayed, E. A. (2019) Antiulcerogenic effect of Cuphea ignea extract against ethanol-induced gastric ulcer in rats. BMC Complement Altern. Med. 19: 345.
Al-Quraishy, S., Othman, M. S., Dkhil, M. A. and Abdel Moneim, A. E. (2017) Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities. Biomed Pharmacother. 91: 338-349.
Yeo, D., Hwang, S. J., Song, Y. S. and Lee, H. J. (2021) Humulene inhibits acute gastric mucosal injury by enhancing mucosal integrity. Antioxidants 10: 761.
Nomura, A., Stemmermann, G. N., Chyou, P. H., Perez-Perez, G. I. and Blaser, M. J. (1994) Helicobacter pylori infection and the risk for duodenal and gastric ulceration. Ann. Intern. Med. 120: 977-981.
Mousa, A. M., El-Sammad, N. M., Hassan, S. K., Madboli, A. E. N. A., Hashim, A. N., Moustafa, E. S., Bakry, S. M. and Elsayed, E. A. (2019) Antiulcerogenic effect of Cuphea ignea extract against ethanol-induced gastric ulcer in rats. BMC Complement Altern. Med. 19: 345.
Al-Quraishy, S., Othman, M. S., Dkhil, M. A. and Abdel Moneim, A. E. (2017) Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities. Biomed Pharmacother. 91: 338-349.
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