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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
2’-Hydroxy-3’,4’-methylenedioxy-3,4,5-trimethoxychalcone (HMTC) is a newly synthesized chalcone that affects proliferation, cytotoxic potential and apoptosis in human leukemia cells. However, no validated determination method has been described so far for HMTC in biological samples. Thus, we developed a liquid chromatographic method using a tandem mass spectrometry to determine HMTC in rat plasma. Liquid-liquid extraction with ethyl acetate was used for the clean-up procedure. The analyte was separated on a reversedphase column with mobile phase of distilled water and acetonitrile (2:8, v/v, including 0.1 % formic acid). The ion transition of the precursor to the product ion was principally deprotonated ions [M-H]− at m/z 356.8 → 327.2 for HMTC. This analytical method was successfully applied in pharmacokinetic study of HMTC after intravenous administration in rats.
목차
Abstract
1. Introduction
2. Experimental
3. Results and Discussion
4. Conclusions
References
참고문헌 (13)
참고문헌 신청
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S. Sale, R. G. Tunstall, K. C. Ruparelia, P. C. Butler, G. A. Potter, W. P. Steward, and A. J. Gescher, Investigational New Drugs, 24, 459-464 (2006).
F. Herencia, M. L. Ferrfindiz, A. Ubeda, J. N. Dominguez, J. E. Charris, G. M. Lobo, and M. J. Alcaraz, Bioorganic & Medicinal Chemistry Letters, 8, 1169-1174 (1998).
R. J. Anto, K. Sukumaran, G. Kuttan, M. N. A. Rao, V. Subbaraju, and R. Kuttan, Cancer Letters, 97, 33-37 (1995).
P. N. Bandeira, T. L. G. Lemos, H. S. Santos, M. C. S. Carvalho, D. P. Pinheiro, M. O. M. Filho, C. Pessoa, F. W. A. Barros-Nepomuceno, T. H. S. Rodrigues, P. R. V. Ribeiro, H. S. Magalhães, and A. M. R. Teixeira, Medicinal Chemistry Research, 28, 2037-20
S. Sale, R. G. Tunstall, K. C. Ruparelia, P. C. Butler, G. A. Potter, W. P. Steward, and A. J. Gescher, Investigational New Drugs, 24, 459-464 (2006).
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