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논문 기본 정보

자료유형
학술저널
저자정보
(Department of Pharmaceutical Engineering College of Medical and Life Science Silla University Busan) (Creative Innovation Research Center Cosmecca Korea Co. Ltd. Gyeonggi-do 13488 Republic of KoreaDepa) (Department of Pharmaceutical Engineering College of Medical and Life Science Silla University Busan) (Department of Pharmaceutical Engineering College of Medical and Life Science Silla University Busan) (Creative Innovation Research Center Cosmecca Korea Co. Ltd. Gyeonggi-do 13488 Republic of Korea) (Creative Innovation Research Center Cosmecca Korea Co. Ltd. Gyeonggi-do 13488 Republic of Korea) (Creative Innovation Research Center Cosmecca Korea Co. Ltd. Gyeonggi-do 13488 Republic of Korea) (Bio Convergence R) (Bio Convergence R&D Center CoseedBioPharm Co. Ltd. Chungbuk 28161 Republic of Korea) (Bio Convergence RBio Convergence R&D Center CoseedBioPharm Co. Ltd. Chungbuk 28161 Republic of) (Bio Convergence RBio Convergence R&D Center CoseedBioPharm Co. Ltd. Chungbuk 28161 Republic of) (Department of Korean Medical Ophthalmology & Otolaryngology & Dermatology College of Korean) (Department of Cosmetic Sciences and Beauty Biotechnology Semyung University Chungbuk 27136 Republic) (R&D Center TS Trillion Co. Ltd. Seoul 07206 Republic of Korea) (R&D Center TS Trillion Co. Ltd. Seoul 07206 Republic of Korea) (Bio Convergence R&D Center CoseedBioPharm Co. Ltd. Chungbuk 28161 Republic of Korea) (Department of Pharmaceutical Engineering College of Medical and Life Science Silla University Busan)
저널정보
한국미생물생명공학회 한국미생물·생명공학회지 한국미생물·생명공학회지 제50권 제4호
발행연도
수록면
533 - 547 (15page)
DOI
10.48022/mbl.2206.06011

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초록· 키워드

This study investigated the hair growth effect of Schisandra chinensis extract (TS-SC) and TS-SC fermented by Lactobacillus plantarum (TS-SCLF) on human dermal papilla cells (hDPCs). The production of vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF-1), keratinocyte growth factor/ fibroblast growth factor 7 (KGF/FGF-7) and hepatocyte growth factor (HGF), transforming growth factor beta 1 (TGF-β1) were examined. The secretion rates of VEGF and KGF/FGF-7 were high in TS-SC, and the secretion rates of IGF-1 and HGF were high in TS-SCLF. TGF-β1 was inhibited in a concentration-dependent manner in all samples. Gene expression of VEGF, IGF-1, KGF, HGF and alkaline phosphatase, relevant to hair growth, were examined. The data revealed that TS-SC and TS-SCLF successfully promoted hair growth in hDPCs. The IGF-1 gene was expressed in a dose-dependent manner in TS-SCLF. These results indicate that TS-SC and TS-SCLF fermented extract effectively promoted hair growth and gene expression relevant to hair growth in hDPCs. Used in clinical trials the test substance ‘CMK-LPF01’ showed a statistically significant increase in the number of hairs at 8 weeks, 16 weeks, and 24 weeks compared to before product use, and a change in hair growth, a secondary efficacy evaluation variable. Through additional research in the future, it is expected that “CMK-LPF01” can be developed as a functional material that can help alleviate symptoms of hair loss.
#Schisandra chinensis #Lactobacillus plantarum #VEGF #IGF
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