안면신경 손상 후 안면신경 원위부에서 톨 유사 수용체(Toll-Like Receptor) Messenger Ribonucleic Acid의 발현 양상

민혜규; 여승근; 이재민; 정준양; 김영일; 김상훈

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자료유형: 학술저널

저자정보: 민혜규 (경희대학교 이비인후과) 여승근 (경희대학교) 이재민 (경희대학교 의과대학) 정준양 (경희대학교 의과대학 해부학교실) 김영일 (경희대학교 의과대학 경희의료원 의과학연구원) 김상훈 (경희대학교 의과대학 이비인후과학교실)

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후-두경부외과학회지 제65권 제8호

발행연도: 2022.8

수록면: 437 - 443 (7page)

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Background and Objectives This study aimed to evaluate whether Toll-like receptors(TLRs) messenger ribonucleic acid (mRNA) were expressed in the facial nerve after incurringa crush or an injury of the facial nerve. Materials and Method An adult Sprague-Dawley underwent a crush or injury of the unilateralfacial nerve. The crush or injury was incurred by a cutting at the midpoint between thefacial nerve trunk and its branch. The whisker movement of vibrissae muscle was examined 4and 14 days after injury. Real-time polymerase chain reaction was performed for the normalfacial nerve taken from the left side and the damaged nerve taken from the right side. Results On the 4th day of injury, the expression of TLR 9, 13 mRNA was significantly lowerin the crush and injured groups than in the control group (p<0.05). On the 14th day of injury,the expression of TLR 2 mRNA was significantly higher in the injured group than in thecontrol group (p<0.05). Conclusion The expressions of TLR 9, 13 mRNA in the distal facial nerve after injury inthe crush and injured groups were significantly lower than that in the control group, but theexpression of TLR 2 mRNA in the injured group was significantly higher. Therefore, TLRsmay be involved in facial nerve damage and regeneration.

#Facial nerve injury #Facial palsy #Nerve regeneration #Toll like receptor.

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민혜규

소속기관 Department of Otorhinolaryngology-Head and Neck Surgery Kyung Hee University Medical Center