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논문 기본 정보

자료유형
학술저널
저자정보
Jihye Um (National Medical Center) Youn Young Choi (National Medical Center) Gayeon Kim (National Medical Center) Min-Kyung Kim (National Medical Center) Kyung-Shin Lee (National Medical Center) Ho Kyung Sung (National Medical Center) Byung Chul Kim (Korea Disease Control and Prevention Agency) Yoo-kyoung Lee (Korea Disease Control and Prevention Agency) Hee-Chang Jang (Korea Disease Control and Prevention Agency) Ji Hwan Bang (Seoul Metropolitan Government-Seoul National University Boramae Medical Center) Ki-hyun Chung (National Medical Center) Myoung-don Oh (Seoul National University College of Medicine) Jun-Sun Park (National Medical Center) Jaehyun Jeon (National Medical Center)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.9
발행연도
2022.3
수록면
1 - 6 (6page)
DOI
10.3346/jkms.2022.37.e70

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초록· 키워드

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Concerns about the effectiveness of current vaccines against the rapidly spreading severe acute respiratory syndrome-coronavirus-2 omicron (B.1.1.529) variant are increasing. This study aimed to assess neutralizing antibody activity against the wild-type (BetaCoV/Korea/ KCDC03/2020), delta, and omicron variants after full primary and booster vaccinations with BNT162b2. A plaque reduction neutralization test was employed to determine 50% neutralizing dilution (ND50) titers in serum samples. ND50 titers against the omicron variant (median [interquartile range], 5.3 [< 5.0?12.7]) after full primary vaccination were lower than those against the wild-type (144.8 [44.7?294.0]) and delta (24.3 [14.3?81.1]) variants. Furthermore, 19/30 participants (63.3%) displayed lower ND50 titers than the detection threshold (< 10.0) against omicron after full primary vaccination. However, the booster vaccine significantly increased ND50 titers against BetaCoV/Korea/KCDC03/2020, delta, and omicron, although titers against omicron remained lower than those against the other variants (P < 0.001). Our study suggests that booster vaccination with BNT162b2 significantly increases humoral immunity against the omicron variant.

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