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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.11
- 수록면
- 531 - 541 (11page)
- DOI
- https://doi.org/10.5468/ogs.22108
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ObjectiveTriphenyl phosphate (TPHP) is one of the most commonly used organophosphorus flame retardants that mayaccumulate in the environment. However, its effects on human reproductive organs have not been well studied. Weaimed to investigate the in vitro effects of TPHP in human Ishikawa endometrial cancer cells to elucidate how TPHPexposure disrupts intracellular signaling and cell proliferation in reproductive tissues.
MethodsHuman Ishikawa endometrial cancer cells were exposed to TPHP.
ResultsExposure to TPHP elevated the levels of estrogen receptor (ER) α and progesterone receptor-B and reduced ER β inhuman Ishikawa endometrial cancer cells. TPHP stimulated phosphoinositide 3-kinase/protein kinase B and mitogenactivatedprotein kinase/ extracellular signal-regulated kinases 1/2 kinase signaling, which may contribute to theactivation of ER function and induce nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated Bcells (NF-κB) in human Ishikawa endometrial cancer cells. Activated ER and NF-κB stimulate the expression of cyclin D1/cyclin-dependent kinase (CDK) 4/CDK6, indicating cell cycle progression and proliferation.
ConclusionThis report may provide new information on the molecular mechanisms underlying how TPHP exposure dysregulatesthe cellular physiology of the human endometrium.
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