Radiation-Induced Ocular Surface Disorders and Retinopathy: Ocular Structures and Radiation Dose-Volume Effect

Ozlem Ozkaya Akagunduz; Suzan Guven Yilmaz; Emin Tavlayan; Mine Esen Baris; Filiz Afrashi; Mustafa Esassolak

doi:10.4143/crt.2021.575

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자료유형: 학술저널

저자정보: Ozlem Ozkaya Akagunduz (Ege University Faculty of Medicine Izmir Turkey) Suzan Guven Yilmaz (Ege University Faculty of Medicine Izmir Turkey) Emin Tavlayan (Ege University Faculty of Medicine Izmir Turkey) Mine Esen Baris (Ege University Faculty of Medicine Izmir Turkey) Filiz Afrashi (Ege University Faculty of Medicine Izmir Turkey) Mustafa Esassolak (Ege University Faculty of Medicine Izmir Turkey)

저널정보: 대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제54권 제2호

발행연도: 2022.4

수록면: 417 - 423 (7page)

DOI: 10.4143/crt.2021.575

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Purpose This study aimed to evaluate the radiation-induced adverse effects on ocular structures in head and neck cancer patients and investigate the radiation dose-volume effects on the cornea, lacrimal gland, retina, optic nerve and chiasm.Materials and Methods A total of 38 eyes of 19 patients were included in this prospective, cohort study. All patients underwent complete ophthalmological examination in addition to contrast sensitivity, visual field and visual evoked potentials (VEP) tests. Ophthalmological examinations and psychophysical tests were performed in 6th, 12th, 18th, 24th months and in the last visit. The relationship between the ophthalmologic findings, and the radiation doses below and above the cut-off values was evaluated.Results Contrast sensitivity decrease and visual field deterioration were observed in 42% of the patients in the last visit (median 26 months) whereas a prolonged latency and decreased amplitude of P100 wave in VEP was observed in 58% and 33% of the eyes, respectively at 24th month. Totally 16 patients (84.2%) developed dry eye disease and eight of them received radiotherapy below tolerance doses and had mild to moderate dry eye findings. Radiation-induced retinopathy was observed in three of the eyes in eight patients who received radiation above tolerance dose.Conclusion Head and neck cancers treated with radiotherapy, resulted in various ophthalmic complications. All patients who are treating with radiotherapy should be evaluated by an ophthalmologist in terms of anterior and posterior segment damage, even if the radiation dose is below the tolerance limit.

#Radiotherapy #Radiation-induced toxicity #Head and neck neoplasms #Ocular tolerance doses #Ocular surface #Radiation retinopathy

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