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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한양대학교 세라믹공정연구센터 Journal of Ceramic Processing Research Journal of Ceramic Processing Research 제23권 제5호
- 발행연도
- 2022.10
- 수록면
- 725 - 736 (12page)
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One of the most promising options for bone defects or lesions is the use of synthetic materials as bone substitutes. Thus, theobjective of the present work was to synthesize a nanocomposite of HA and BNNS, as a reinforcement phase, to obtain amaterial with satisfactory mechanical properties as well as bifunctional, with the incorporation of ciprofloxacin to evaluate thepotential of the system as a drug delivery. The nanocomposites obtained were characterized by X-ray diffraction (XRD),Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG), nitrogen adsorption by BET and BJH methods,scanning electron microscopy (SEM) and electron microscopy transmission (TEM). The Vickers hardness test andnanoindentation showed an increase in the mechanical strength of the nanocomposites with the insertion of the reinforcementphase, thus corroborating the promising character of BNNS as a reinforcement agent for HA. A biocompatibility assay wasperformed to assess the potential of the samples as effective biomaterials. The nanocomposites showed high cell viabilityindicating that the system does not present cytotoxicity. Drug loading and in vitro release show that the system can providerapid drug delivery, giving antibacterial effects at the infected site, indicating that the nanocomposite, a bioceramic, is suitablefor the application.
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