Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer

이현도; 이해원; 박은정; 강정현; 백승혁

doi:10.3393/ac.2021.00640.0091

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자료유형: 학술저널

저자정보: 이현도 (Yonsei University College of Medicine) 이해원 (Asan Medical Center) 박은정 (Gangnam Severance Hospital) 강정현 (Gangnam Severance Hospital) 백승혁 (Gangnam Severance Hospital)

저널정보: 대한대장항문학회 Annals of Coloproctology Annals of Coloproctolgy Vol.38 No.3

발행연도: 2022.6

수록면: 197 - 206 (10page)

DOI: 10.3393/ac.2021.00640.0091

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Purpose: This study aimed to investigate the clinicopathologic features and survival in patients with both breast cancer (BrC) and colorectal cancer (CRC).Methods: Between 1996 and 2019, patients who were diagnosed with both BrC and CRC were evaluated retrospectively. Patients with distant metastasis, palliative resection, and previous cancer histories except for BrCs or CRCs were excluded. Altogether, 105 patients were divided into the B=C group (n=21), B-first group (n=40), and C-first group (n=44) according to the definition of synchronous and metachronous cancers. The clinicopathologic features and overall survival were evaluated.Results: TNM stages and histologic types were comparable among the 3 groups (P=0.434). The interval of diagnosis was 67.1±40.4 and 59.3±47.2 months in the B- and C-first groups, respectively. The incidence of adjuvant chemotherapy in the B-first group was 57.5%, which was higher than the B=C and C-first groups (P<0.001). The estrogen receptor, progesterone receptor, Ki-67, and HER-2 molecular markers were not significantly different among the groups. The overall survival of the B-first group showed lower survival rates than the C-first group (P=0.039). In the logistic regression, HER-2 status (hazard ratio [HR], 11.9; P=0.032) and lymph node metastasis of CRC (HR, 5.8; P=0.036) were prognostic factors affecting overall survival.Conclusion: B-first group had poorer survival outcomes than the C-first group in patients with the metachronous BrC and CRC. HER2 positivity and CRC lymph node metastasis may be prognostic factors that affect overall survival in these patients. The findings support that a colorectal cancer screening program should be included during BrC surveillance.

#Neoplasms #Breast neoplasms #Colorectal neoplasms #Survival

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