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논문 기본 정보

자료유형
학술저널
저자정보
Kennedy Mensah Osei (1Department of Laboratory Tamale Teaching Hospital Tamale Ghana) 최희강 (연세대학교 의과대학 진단검사의학교실 및 세균내성연구소) David Eklu Zeyeh (Department of Laboratory Tamale Teaching Hospital Tamale Ghana) Salifu Alikamatu (Department of Laboratory Tamale Teaching Hospital Tamale Ghana) Esther Owusu Boateng (Department of Laboratory Tamale Teaching Hospital Tamale Ghana) Vandarith Nov (Department of Global Health Security Yonsei University Graduate School of Public Health) Le Phuong Nguyen (Department of Laboratory Medicine and Research Institute of Bacterial Resistance Yonsei University) Khadija Kubura (Department of Laboratory Tamale Teaching Hospital Tamale Ghana) Bernard Bobzah (Department of Laboratory Tamale Teaching Hospital Tamale Ghana) 용동은 (연세대학교)
저널정보
대한임상미생물학회 Annals of Clinical Microbiology Annals of Clinical Microbiology 제25권 제1호
발행연도
2022.3
수록면
1 - 11 (11page)
DOI
10.5145/ACM.2022.25.1.1

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Background: A variety of clinically important pathogens have developed multidrug resistance(MDR), which threatens global public health. This study aimed to determine the incidence,patterns, and trends of MDR of gram-negative bacterial isolates in clinical specimens in theTamale Teaching Hospital, Ghana. Methods: This retrospective study analyzed gram-negative bacterial isolates andantimicrobial susceptibility test (AST) results of patients who visited the Tamale TeachingHospital laboratory between 2017 and 2019. Results: A total of 2,779 gram-negative bacterial isolates and their phenotypic AST resultswere analyzed. From these, 1,297 gram-negative bacteria (46.7%) were isolated from urinesamples, while the rest were isolated from sputum (20.9%), wound (14.3%), and swabs(11.7%) samples, etc. Escherichia coli (23.8%) was the most common gram-negative pathogenfound predominantly in the urine samples (33.2%). All gram-negative bacteria isolatedbetween 2017 and 2019 showed high MDR. Klebsiella pneumoniae gradually increased itsMDR from 84.0% in 2017, 89.5% in 2018, to 95.1% in 2019. On the other hand, the MDR ratesin Pseudomonas aeruginosa were approximately 65.8%, varying from 59.5% in 2017 to78.7% in 2019. Among tested antimicrobials, amikacin was the most effective. Resistance toamikacin in Enterobacter spp., E. coli, and K. pneumoniae in vitro were 16.2%, 11.8%, and17.7%, respectively. Conclusion: The study has shown that the high levels of MDR in gram-negative bacteriaisolated may be associated with the infections recorded at the Tamale Teaching Hospital. The major gram-negative pathogens isolated have resistance to penicillins, cephalosporins,and fluoroquinolones. Aminoglycosides can offer high antibiotic activity to overcome gramnegativebacterial resistance. Further studies will be needed to decide policy direction oninfection prevention and control, and antimicrobial stewardship programs

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