메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Satoshi Sugino (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Ken Inoue (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Reo Kobayashi (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Ryohei Hirose (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Toshifumi Doi (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Akihito Harusato (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Osamu Dohi (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Naohisa Yoshida (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Kazuhiko Uchiyama (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Takeshi Ishikawa (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Tomohisa Takagi (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Hiroaki Yasuda (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Hideyuki Konishi (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr) Yasuko Hirai (Department of Human Immunology and Nutrition Science Kyoto Prefectural University of Medicine Kyoto) Katsura Mizushima (Department of Human Immunology and Nutrition Science Kyoto Prefectural University of Medicine Kyoto) Yuji Naito (Department of Human Immunology and Nutrition Science Kyoto Prefectural University of Medicine Kyoto) Toshifumi Tsuji (Department of Gastroenterology and Hepatology Fukuchiyama City Hospital Kyoto Japan) Takashi Okuda (Department of Gastroenterology and Hepatology Fukuchiyama City Hospital Kyoto Japan) Keizo Kagawa (Department of Gastroenterology and Hepatology Fukuchiyama City Hospital Kyoto Japan) Makoto Tominaga (Division of Cell Signaling National Institute for Physiological Sciences National Institutes of Nat) Yoshito Itoh (Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Gr)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.28 No.4
발행연도
2022.10
수록면
693 - 705 (13page)
DOI
10.5056/jnm21198

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
"Background/Aims Several studies have assessed the effect of cool temperature on colonic peristalsis. Transient receptor potential melastatin 8 (TRPM8) is a temperature-sensitive ion channel activated by mild cooling expressed in the colon. We examined the antispasmodic effect of cool temperature on colonic peristalsis in a prospective, randomized, single-blind trial and based on the video imaging and intraluminal pressure of the proximal colon in rats and TRPM8-deficient mice. Methods In the clinical trial, we randomly assigned a total of 94 patients scheduled to undergo colonoscopy to 2 groups: the mildly cool water (n = 47) and control (n = 47) groups. We used 20 mL of 15°C water for the mildly cool water. The primary outcome was the proportion of subjects with improved peristalsis after treatment. In the rodent proximal colon, we evaluated the intraluminal pressure and performed video imaging of the rodent proximal colon with cool water administration into the colonic lumen. Clinical trial registry website (Trial No. UMIN-CTR; UMIN000030725). Results In the randomized controlled trial, after treatment, the proportion of subjects with no peristalsis with cool water was significantly higher than that in the placebo group (44.7% vs 23.4%; P < 0.05). In the rodent colon model, cool temperature water was associated with a significant decrease in colonic peristalsis through its suppression of the ratio of peak frequency (P < 0.05). Cool temperature-treated TRPM8-deficient mice did not show a reduction in colonic peristalsis compared with wild-type mice. Conclusion For the first time, this study demonstrates that cool temperature-dependent suppression of colonic peristalsis may be associated with TRPM8 activation."
#Animals #Colon #Peristalsis #Single-blind method #Temperature

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청
참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0