Relationship between metabolic syndrome and its components with bladder cancer: a systematic review and meta-analysis in cohort studies

Ahmadinezhad Mozhgan; Arshadi Maedeh; Hesari Elahe; Sharafoddin Maedeh; Azizi Hosein; Khodamoradi Farzad

doi:10.4178/epih.e2022050

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저자정보: Ahmadinezhad Mozhgan (Department of Epidemiology and Biostatistics School of Public Health Tehran University of Medical S) Arshadi Maedeh (Department of Epidemiology and Biostatistics School of Public Health Tehran University of Medical S) Hesari Elahe (Department of Epidemiology and Biostatistics School of Public Health Tehran University of Medical S) Sharafoddin Maedeh (Department of Epidemiology and Biostatistics School of Public Health Tehran University of Medical S) Azizi Hosein (Research Center of Psychiatry and Behavioral Sciences Tabriz University of Medical Sciences) Khodamoradi Farzad (Department of Social Medicine Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences)

저널정보: 한국역학회 Epidemiology and Health Epidemiology and Health Vol.44

발행연도: 2022.1

수록면: 1 - 11 (11page)

DOI: 10.4178/epih.e2022050

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A previous meta-analysis, entitled “The association between metabolic syndrome and bladder cancer susceptibility and prognosis: an updated comprehensive evidence synthesis of 95 observational studies involving 97,795,299 subjects,” focused on all observational studies, whereas in the present meta-analysis, we focused on cohort studies to obtain more accurate and stronger evidence to evaluate the association between metabolic syndrome and its components with bladder cancer. PubMed, Embase, Scopus, and Web of Science were searched to identify studies on the association between metabolic syndrome and its components with bladder cancer from January 1, 2000 through May 23, 2021. The pooled relative risk (RR) and 95% confidence intervals (CI) were used to measure this relationship using a random-effects meta-analytic model. Quality appraisal was undertaken using the Newcastle-Ottawa Scale. In total, 56 studies were included. A statistically significant relationship was found between metabolic syndrome and bladder cancer 1.09 (95% CI, 1.02 to 1.17), and there was evidence of moderate heterogeneity among these studies. Our findings also indicated statistically significant relationships between diabetes (RR, 1.23; 95% CI, 1.16 to 1.31) and hypertension (RR, 1.07; 95% CI, 1.01 to 1.13) with bladder cancer, but obesity and overweight did not present a statistically significant relationship with bladder cancer. We found no evidence of publication bias. Our analysis demonstrated statistically significant relationships between metabolic syndrome and the risk of bladder cancer. Furthermore, diabetes and hypertension were associated with the risk of bladder cancer.

#: Urinary bladder neoplasm #Meta analysis #Metabolic syndrome #Metabolic syndrome components #Cohort studies

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Ahmadinezhad Mozhgan

소속기관 Department of Epidemiology and Biostatistics School of Public Health Tehran University of Medical S