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논문 기본 정보

자료유형
학술저널
저자정보
Kesary Yuval (Sackler Faculty of Medicine Tel Aviv University P. O. Box 39040 6997801 Tel Aviv Israel) Dekel Shmuel (Sackler Faculty of Medicine Tel Aviv University P. O. Box 39040 6997801 Tel Aviv Israel) Schwarzkopf Ran (Department of Orthopedic Surgery NYU Langone Health NYU Langone Orthopedic Hospital New York NY) Singh Vivek (Department of Orthopedic Surgery NYU Langone Health NYU Langone Orthopedic Hospital New York NY) Frenkel-Rutenberg Tal (Orthopedic Department Rabin Medical Center Beilinson Hospital Petah Tikva Israel) Greenberg Arie (Department of Orthopedic Surgery Kaplan Medical Center Rehovot Israel) Snir Nimrod (Tel Aviv Sourasky Medical Center Ichilov Hospital Israel)
저널정보
대한슬관절학회 Knee Surgery and Related Research Knee Surgery and Related Research 제34권
발행연도
2022.3
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2 - 2 (1page)

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One experimental way of changing the VMO:VL ratio is by injecting BoNT-A into the VL muscle combined with a tailored exercise program, thus preventing patellar maltracking through the achievement of normal muscle balance [19,37?40]. BoNT-A is a neurotoxin that weakens the muscle by blocking the pre-synaptic acetylcholine release, allowing weakness relative to the given dose of a muscle to be achieved for 12 weeks to 6 months [41?43]. The BoNT-A action is time-limited, and the muscle function is renewed by regeneration of new nerve sprouts within one month [44]. Previous studies have established the utility of intramuscular injection of BoNT-A to address focal muscle overactivity to manage neurological conditions [45]; however, its use for treatment of musculoskeletal conditions is not as well reported in the literature [38]. In the setting of PFPS, BoNT-A injections have the potential to address the proposed imbalance between a relatively overactive VL muscle and its less active synergists, including the VMO muscle. This provides a unique opportunity for aimed muscle re-training and rebuilding of more normal quadriceps muscle activation patterns and joint function. We believe that this is more viably accomplished with explicit and centered muscle re-training fortified by expert healthcare providers, rather than just from ordinary every day movements. Treatment of PFPS by utilizing BoNT-A injections provides a cost and time effective alternative to not only ongoing conservative management but also surgical intervention for patients experiencing refractory anterior knee pain. It significantly improved functional outcomes and reduced pain in patients who had exhausted conservative treatment methodologies. However, larger prospective studies are needed to evaluate the effectiveness of the herein described intervention and characterize the patients who will benefit most from it.

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