지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 73 - 81 (9page)
이용수
초록· 키워드
오류제보하기
The ?-secretase complex represents an evolutionarily conserved family of transmembrane aspartyl proteases that cleave numerous type-I membrane proteins, including the ?-amyloid precursor protein (APP) and the receptor Notch. All known rare mutations in APP and the ?-secretase catalytic component, presenilin, which lead to increased amyloid ?-peptide production, are responsible for early-onset familial Alzheimer’s disease. ?-amyloid protein precursor-like (APPL) is the Drosophila ortholog of human APP. Here, we created Notch- and APPL-based Drosophila reporter systems for in vivo monitoring of ?-secretase activity. Ectopic expression of the Notch- and APPL-based chimeric reporters in wings results in vein truncation phenotypes. Reporter-mediated vein truncation phenotypes are enhanced by the Notch gain-of-function allele and suppressed by RNAi-mediated knockdown of presenilin. Furthermore, we find that apoptosis partly con-tributes to the vein truncation phenotypes of the APPL-based reporter, but not to the vein truncation phenotypes of the Notch-based reporter. Taken together, these results suggest that both in vivo reporter systems provide a pow-erful genetic tool to identify genes that modulate ?-secretase activity and/or APPL metabolism.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Bai, X. C. / 2015 / An atomic structure of human γ-secretase / Nature 525:212~217
Bailey, A. M. / 1995 / Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity / Genes Dev 9:2609~2622
Bertet, C. / 2014 / Temporal patterning of neuroblasts controls Notch-mediated cell survival through regulation of Hid or Reaper / Cell 158:1173~1186
Bier, E. / 2005 / Drosophila, the golden bug, emerges as a tool for human genetics / Nat. Rev. Genet 6:9~23
Brachmann, C. B. / 2003 / Patterning the fly eye : the role of apoptosis / Trends Genet 19:91~96
Bailey, A. M. / 1995 / Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity / Genes Dev 9:2609~2622
Bertet, C. / 2014 / Temporal patterning of neuroblasts controls Notch-mediated cell survival through regulation of Hid or Reaper / Cell 158:1173~1186
Bier, E. / 2005 / Drosophila, the golden bug, emerges as a tool for human genetics / Nat. Rev. Genet 6:9~23
Brachmann, C. B. / 2003 / Patterning the fly eye : the role of apoptosis / Trends Genet 19:91~96
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Characterization of β-Secretase Inhibitory Peptide Purified from Blackfin flounder (Glyptocephalus stelleri) Protein Hydrolysate
한국해양바이오학회지
2018 .06
-
Magnetic Field Analysis of Notched SPMSM Using Conformal Mapping
Journal of Magnetics
2019 .03
-
Effects of δ-Catenin on APP by Its Interaction with Presenilin-1
Molecules and Cells
2019 .01
-
Validation study of in vitro potency test method using reporter gene for the therapeutic monoclonal antibodies
한국분석과학회 학술대회
2019 .05
-
RRV-induced biliary atresia in neonatal mice involves CD8?+?T lymphocyte killer cells and the Notch signaling pathway
Genes & Genomics
2021 .11
-
Heterologous protein production using Psychrobacter sp. PAMC21119 analyzed with a green fluorescent protein-based reporter system
극지연구소 초록집
2024 .07
-
Construction of 3-Hydroxypropionic Acid Inducible Reporter System in Escherichia coli
한국미생물학회 학술대회논문집
2019 .04
-
Effects of sarah/nebula knockdown on Ab42-induced phenotypes during Drosophila development
Genes & Genomics
2016 .01
-
Bias selectable dual-color nBn photodetector for short- and mid-wavelength infrared detection
한국진공학회 학술발표회초록집
2020 .08
-
Spatial Randomness Applied to the Assessment of the Association Between a Disease and a Phenotype
Journal of The Korean Data Analysis Society
2019 .01
-
Adzuki bean (Vigna angularis) extract reduces amyloid-β aggregation and delays cognitive impairment in Drosophila models of Alzheimer’s disease
Nutrition Research and Practice
2019 .02
-
Adzuki bean (Vigna angularis) extract reduces amyloid-β aggregation and delays cognitive impairment in Drosophila models of Alzheimer’s disease
Nutrition Research and Practice
2019 .02
-
Maximal Truncation of Guide RNAs Enabled Efficient CRISPR-mediated Microbial Genome Editing
한국미생물학회 학술대회논문집
2022 .10
-
Effects of the fermented Zizyphus jujuba in the amyloid β25-35-induced Alzheimer"s disease mouse model
Nutrition Research and Practice
2021 .04
-
Effects of the fermented Zizyphus jujuba in the amyloid β25-35-induced Alzheimer"s disease mouse model
Nutrition Research and Practice
2021 .04
-
Synergistic Ensemble of Optogenetic Actuators and Dynamic Indicators in Cell Biology
Molecules and Cells
2018 .09
-
Development of a Reporter System Monitoring Regulated Intramembrane Proteolysis of the Transmembrane bZIP Transcription Factor ATF6α
Molecules and Cells
2019 .01
-
Personalized Medicine Based on Deep Human Phenotyping
한국미생물학회 학술대회논문집
2022 .10
-
Function and regulation of nitric oxide signaling in Drosophila
Molecules and Cells
2024 .01
-
Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos
Molecules and Cells
2017 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0