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논문 기본 정보

자료유형
학술저널
저자정보
Mohd M. Khan (University of Maryland School of Medicine) Bao Quoc Tran (U.S. Army Edgewood Chemical Biological Center) 장윤진 (전북대학교) 박수현 (전북대학교병원) William E. Fondrie (University of Maryland School of Medicine) Khadiza Chowdhury (University of Maryland School of Medicine) 윤성환 (University of Maryland) David R. Goodlett (University of Maryland) 채수완 (전북대학교) 채한정 (전북대학교) 서승영 (전북대학교) 구영아 (University of Maryland)
저널정보
한국분자세포생물학회 Molecules and Cells Molecules and Cells 제40권 제7호
발행연도
2017.7
수록면
466 - 475 (10page)

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Dietary supplements have exhibited myriads of positive health effects on human health conditions and with the advent of new technological advances, including in the fields of proteomics, genomics, and metabolomics, biological and pharmacological activities of dietary supplements are being evaluated for their ameliorative effects in human ailments. Recent interests in understanding and discovering the molecular targets of phytochemical-gene-protein-metabolite dynamics resulted in discovery of a few protein signature candidates that could potentially be used to assess the effects of dietary supplements on human health. Persimmon (Diospyros kaki) is a folk medicine, commonly used as dietary supplement in China, Japan, and South Korea, owing to its different beneficial health effects including anti-diabetic implications. However, neither mechanism of action nor molecular biomarkers have been discovered that could either validate or be used to evaluate effects of persimmon on human health. In present study, Mass Spectrometry (MS)-based proteomic studies were ac-complished to discover proteomic molecular signatures that could be used to understand therapeutic potentials of persimmon leaf extract (PLE) in diabetes amelioration. Saliva, serum, and urine samples were analyzed and we propose that salivary proteins can be used for evaluating treatment effectiveness and in improving patient compliance. The present discovery proteomics study demonstrates that salivary proteomic profile changes were found as a result of PLE treatment in prediabetic subjects that could specifically be used as potential protein signature candidates.

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