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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 466 - 475 (10page)
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초록· 키워드
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Dietary supplements have exhibited myriads of positive health effects on human health conditions and with the advent of new technological advances, including in the fields of proteomics, genomics, and metabolomics, biological and pharmacological activities of dietary supplements are being evaluated for their ameliorative effects in human ailments. Recent interests in understanding and discovering the molecular targets of phytochemical-gene-protein-metabolite dynamics resulted in discovery of a few protein signature candidates that could potentially be used to assess the effects of dietary supplements on human health. Persimmon (Diospyros kaki) is a folk medicine, commonly used as dietary supplement in China, Japan, and South Korea, owing to its different beneficial health effects including anti-diabetic implications. However, neither mechanism of action nor molecular biomarkers have been discovered that could either validate or be used to evaluate effects of persimmon on human health. In present study, Mass Spectrometry (MS)-based proteomic studies were ac-complished to discover proteomic molecular signatures that could be used to understand therapeutic potentials of persimmon leaf extract (PLE) in diabetes amelioration. Saliva, serum, and urine samples were analyzed and we propose that salivary proteins can be used for evaluating treatment effectiveness and in improving patient compliance. The present discovery proteomics study demonstrates that salivary proteomic profile changes were found as a result of PLE treatment in prediabetic subjects that could specifically be used as potential protein signature candidates.
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참고문헌 (71)
참고문헌 신청
Acosta-Martin, A. E. / 2011 / Quantitative mass spectrometry analysis using PAcIFIC for the identification of plasma diagnostic biomarkers for abdominal aortic aneurysm / PLoS One 6:e28698
Ahn, H. S. / 2002 / Antioxidative activity of persimmon and grape seed extract: in vitro and in vivo / Nutr. Res 22:1265~1273
Amara, U. / 2008 / Interaction between the coagulation and complement system / Adv. Exp. Med. Biol 632:71~79
An, B. -J. / 2006 / Inhibition of enzyme activities and the antiwrinkle effect of polyphenol isolated from the Persimmon Leaf (Diospyros kaki folium) on human skin / Dermatol. Surg 31:848~855
Astle, J. / 2007 / Characterization of proteomic and metabolomic responses to dietary factors and supplements / J. Nutr 137:2787~2793
Ahn, H. S. / 2002 / Antioxidative activity of persimmon and grape seed extract: in vitro and in vivo / Nutr. Res 22:1265~1273
Amara, U. / 2008 / Interaction between the coagulation and complement system / Adv. Exp. Med. Biol 632:71~79
An, B. -J. / 2006 / Inhibition of enzyme activities and the antiwrinkle effect of polyphenol isolated from the Persimmon Leaf (Diospyros kaki folium) on human skin / Dermatol. Surg 31:848~855
Astle, J. / 2007 / Characterization of proteomic and metabolomic responses to dietary factors and supplements / J. Nutr 137:2787~2793
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