지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 685 - 695 (11page)
- DOI
- 10.14348/molcells.2017.0073
이용수
초록· 키워드
오류제보하기
Obesity and the metabolic disorders that constitute metabolic syndrome are a primary cause of morbidity and mortality in the world. Nonetheless, the changes in the proteins and the underlying molecular pathways involved in the relevant pathogenesis are poorly understood.
In this study a proteomic analysis of the visceral adipose tissue isolated from metabolically healthy and unhealthy obese pa-tients was used to identify presence of altered pathway(s) leading to metabolic dysfunction. Samples were obtained from 18 obese patients undergoing bariatric surgery and were subdivided into two groups based on the presence or absence of comorbidities as defined by the International Diabetes Federation. Two dimensional difference in-gel electrophoresis coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was carried out. A total of 28 proteins were identified with a statistically significant difference in abundance and a 1.5-fold change (ANOVA, p ? 0.05) between the groups. 11 proteins showed increased abundance while 17 proteins were decreased in the metabolically unhealthy obese compared to the healthy obese. The differentially expressed proteins belonged broadly to three functional categories: (i) protein and lipid metabolism (ii) cytoskeleton and (iii) regulation of other metabolic processes. Network analysis by Ingenuity pathway analysis identified the NF?B, IRK/MAPK and PKC as the nodes with the highest connections within the connectivity map. The top network pathway identified in our protein data set related to cellular movement, hematological system development and function, and immune cell trafficking. The VAT proteome between the two groups differed substantially between the groups which could potentially be the reason for metabolic dysfunction.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Alfadda, A. A. / 2014 / Circulating adipokines in healthy versus unhealthy overweight and obese subjects / Int. J. Endocrinol 2014:170434
Alfadda, A. A. / 2013 / Proteomic analysis of mature adipocytes from obese patients in relation to aging / Exp. Gerontol 48:1196~1203
Badoud, F. / 2015 / Molecular insights into the role of white adipose tissue in metabolically unhealthy normal weight and metabolically healthy obese individuals / FASEB J 29:748~758
Benabdelkamel, H. / 2015 / Mature adipocyte proteome reveals differentially altered protein abundances between lean, overweight and morbidly obese human subjects / Mol. Cell. Endocrinol 401:142~154
Bluher, M. / 2014 / Are metabolically healthy obese individuals really healthy? / Eur. J. Endocrinol 171:R209~R219
Alfadda, A. A. / 2013 / Proteomic analysis of mature adipocytes from obese patients in relation to aging / Exp. Gerontol 48:1196~1203
Badoud, F. / 2015 / Molecular insights into the role of white adipose tissue in metabolically unhealthy normal weight and metabolically healthy obese individuals / FASEB J 29:748~758
Benabdelkamel, H. / 2015 / Mature adipocyte proteome reveals differentially altered protein abundances between lean, overweight and morbidly obese human subjects / Mol. Cell. Endocrinol 401:142~154
Bluher, M. / 2014 / Are metabolically healthy obese individuals really healthy? / Eur. J. Endocrinol 171:R209~R219
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