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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 935 - 944 (10page)
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More than 50% of sepsis cases are associated with pneumonia. Sepsis is caused by infiltration of bacteria into the blood via inflammation, which is triggered by the release of cell wall components following lysis. However, the regulatory mechanism of lysis during infection is not well defined. Mice were infected with Streptococcus pneumoniae D39 wild-type (WT) and lipase mutant (?lipA) intranasally (pneumonia model) or intraperitoneally (sepsis model), and survival rate and pneumococcal colonization were determined. LipA and autolysin (LytA) levels were determined by qPCR and western blotting. S. pneumoniae Spd_1447 in the D39 (type 2) strain was identified as a lipase (LipA). In the sepsis model, but not in the pneumonia model, mice infected with the ?lipA displayed higher mortality rates than did the D39 WT-infected mice. Treatment of pneumococci with serum induced LipA expres-sion at both the mRNA and protein levels. In the presence of serum, the ?lipA displayed faster lysis rates and higher LytA expression than the WT, both in vitro and in vivo. These results indicate that a pneumococcal lipase (LipA) represses autolysis via inhibition of LytA in a sepsis model.
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참고문헌 (38)
참고문헌 신청
Berry, A. M. / 1989 / Contribution of autolysin to virulence of Streptococcus pneumoniae / Infect. Immun 57:2324~2330
Canvin, J. R. / 1995 / The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus / J. Infect. Dis 172:119~123
Chakravortty, D. / 2000 / The inhibitory action of butyrate on lipopolysaccharide-induced nitric oxide production in RAW 264.7murine macrophage cells / J. Endotoxin. Res 6:243~247
Gácser, A. / 2007 / Targeted gene deletion in Candida parapsilosis demonstrates the role of secreted lipase in virulence / J. Clin Invest 117:3049~3058
Gill, S. R. / 2005 / Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain / J. Bacteriol 187:2426~2438
Canvin, J. R. / 1995 / The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus / J. Infect. Dis 172:119~123
Chakravortty, D. / 2000 / The inhibitory action of butyrate on lipopolysaccharide-induced nitric oxide production in RAW 264.7murine macrophage cells / J. Endotoxin. Res 6:243~247
Gácser, A. / 2007 / Targeted gene deletion in Candida parapsilosis demonstrates the role of secreted lipase in virulence / J. Clin Invest 117:3049~3058
Gill, S. R. / 2005 / Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain / J. Bacteriol 187:2426~2438
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