지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 140 - 149 (10page)
- DOI
- 10.14348/molcells.2018.2257
이용수
초록· 키워드
오류제보하기
The TIS21/BTG2/PC3 gene belongs to the antiproliferative gene (APRO) family and exhibits tumor suppressive activity. However, here we report that TIS21 controls lipid metabolism, rather than cell proliferation, under fasting condition. Using microarray analysis, whole gene expression changes were investigated in liver of TIS21 knockout (TIS21-KO) mice after 20 h fasting and compared with wild type (WT). Peroxisome proliferator-activated receptor alpha (PPAR?) target gene expression was almost absent in contrast to increased lipid synthesis in the TIS21-KO mice compared to WT mice. Im-munohistochemistry with hematoxylin and eosin staining revealed that lipid deposition was focal in the TIS21-KO liver as opposed to the diffuse and homogeneous pattern in the WT liver after 24 h starvation. In addition, cathepsin E expression was over 10 times higher in the TIS21-KO liver than that in the WT, as opposed to the significant reduction of thioltransferase in both adult and fetal livers. At present, we cannot account for the role of cathepsin E. However, downregulation of glutaredoxin 2 thioltransferase expression might affect hypoxic damage in the TIS21-KO liver. We suggest that the TIS21/BTG2 gene might be essential to maintain energy metabolism and reducing power in the liver under fasting condition.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Bradbury, A. / 1991 / Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization / Proc. Natl. Acad. Sci. USA 88:3353~3357
Cahill Jr, G.F. / 2006 / Fuel metabolism in starvation / Annu. Rev. Nutr. 26:1~22
Chlabicz, M. / 2011 / Cathepsin E (EC 3.4. 23.34)-a review / Folia Histochem. Cytobiol. 49:547~557
Choi, J.-A. / 2013 / TIS21/BTG2 inhibits invadopodia formation by downregulating reactive oxygen species level in MDAMB-231 cells / J. Cancer Res. Clin. Oncol. 139:1657~1665
Choi, J. / 2016 / Inhibition of breast cancer invasion by TIS21/BTG2/Pc3-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes / Oncogene 35:83
Cahill Jr, G.F. / 2006 / Fuel metabolism in starvation / Annu. Rev. Nutr. 26:1~22
Chlabicz, M. / 2011 / Cathepsin E (EC 3.4. 23.34)-a review / Folia Histochem. Cytobiol. 49:547~557
Choi, J.-A. / 2013 / TIS21/BTG2 inhibits invadopodia formation by downregulating reactive oxygen species level in MDAMB-231 cells / J. Cancer Res. Clin. Oncol. 139:1657~1665
Choi, J. / 2016 / Inhibition of breast cancer invasion by TIS21/BTG2/Pc3-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes / Oncogene 35:83
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