지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 1 - 10 (10page)
- DOI
- 10.1038/s12276-020-00540-4
이용수
초록· 키워드
오류제보하기
Damage-associated molecular patterns (DAMPs) are danger signals (or alarmins) alerting immune cells through pattern recognition receptors (PRRs) to begin defense activity. Moreover, DAMPs are host biomolecules that can initiate a noninflammatory response to infection, and pathogen-associated molecular pattern (PAMPs) perpetuate the inflammatory response to infection. Many DAMPs are proteins that have defined intracellular functions and are released from dying cells after tissue injury or chemo-/radiotherapy. In the tumor microenvironment, DAMPs can be ligands for Toll-like receptors (TLRs) expressed on immune cells and induce cytokine production and T-cell activation. Moreover, DAMPs released from tumor cells can directly activate tumor-expressed TLRs that induce chemoresistance, migration, invasion, and metastasis. Furthermore, DAMP-induced chronic inflammation in the tumor microenvironment causes an increase in immunosuppressive populations, such as M2 macrophages, myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs). Therefore, regulation of DAMP proteins can reduce excessive inflammation to create an immunogenic tumor microenvironment. Here, we review tumor-derived DAMP proteins as ligands of TLRs and discuss their association with immune cells, tumors, and the composition of the tumor microenvironment.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Single-cell RNA-Seq unveils tumor microenvironment
BMB Reports
2017 .06
-
Tumor microenvironment and radioresistance
Experimental and Molecular Medicine
2021 .06
-
In Vitro Reconstruction of Brain Tumor Microenvironment
BioChip Journal
2019 .01
-
Investigation of Natural Killer Cell-tumor Interaction in Dynamic Tumor-on-a chip
한국생물공학회 학술대회
2023 .10
-
Development of Tumor Microenvironment-Modulating Nanoparticles for Improved Anti-Tumor Efficacy of Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2022 .04
-
Rebuilding the microenvironment of primary tumors in humans: a focus on stroma
Experimental and Molecular Medicine
2024 .03
-
A Liposomal Platform for Targeted STING Activation in Tumor Microenvironments
한국생물공학회 학술대회
2023 .10
-
Regulation of Tumor Microenvironment with Polymer-Modified Melittin
한국생물공학회 학술대회
2023 .04
-
Engineered Macrophage via Click Chemistry Enhances Tumor Targeting and Remodels Immunosuprressive Tumor Microenvironment
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Reverse Engineering of Tumor Microenvironment Using Microfluidics and 3D Printing
한국생물공학회 학술대회
2023 .10
-
Tumor Microenvironment-Recognizable Polymeric Conjugates to Foreignize Tumor Cells in Vivo
한국고분자학회 학술대회 연구논문 초록집
2017 .10
-
Adrenergic receptor β2 activation by stress promotes breast cancer progression through macrophages M2 polarization in tumor microenvironment
BMB Reports
2015 .01
-
Emerging role of RUNX3 in the regulation of tumor microenvironment
BMB Reports
2018 .01
-
A new aspect of an old friend: the beneficial effect of metformin on anti-tumor immunity
BMB Reports
2020 .01
-
Engineering of vascularized 3D cancer on a chip modeling for drug delivery
대한기계학회 춘추학술대회
2021 .04
-
Nanocomplex-Mediated in vivo CAR-M1 Macrophage Therapy for Solid Tumors
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
In vitro Tumor Vasculature Model of the Colorectal Cancer Microenvrionment to Evaluate Natural Killer Cell Activity
대한기계학회 춘추학술대회
2021 .04
-
Engineering of tumor microenvironment on a chip for evaluating combination immunotherapy
대한기계학회 춘추학술대회
2021 .04
-
Estimation of Nonlinear Kinematic Hardening Model Parameter for Modeling Nonlinear Dynamic Property of Rock
대한토목학회 학술대회
2020 .10
-
Recent Advances in 3D Bioprinted Tumor Microenvironment
BioChip Journal
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0