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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제2호
- 발행연도
- 2017.3
- 수록면
- 133 - 139 (7page)
이용수
초록· 키워드
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Fluidic shear stress generated by fluid flow in human body contributes to the interactions between nanoparticles (NPs) and cells and may affect cellular distribution and delivery of NPs. Furthermore, different NPs properties may differently influence the cellular delivery and targeting of NPs under the in vivo dynamic environments.
Thus, we reviewed and discussed how fluidic shear stress affects to drug delivery and cellular distribution of diverse NPs under the biomimetic microfluidic shear stress.
Among different physicochemical properties of NPs, size, shape, material type and surface functionality, and surface charge of NPs are critical factors to cellular uptake in presence of fluidic shear stress in dynamic cellular environment.
From previous studies, it suggested that fluidic shear stress stimulated specific endocytosis and prompted cell signaling pathway. The cellular interactions between NPs and cells in drug delivery should be carefully investigated in presence of shear stress which is one of critical factors to show the difference of in vitro and in vivo drug distribution and therapy. The shear-activated drug delivery using NPs were also the scope of this review.
목차
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참고문헌 (51)
참고문헌 신청
Björnmalm M / 2014 / Engineering and evaluating drug delivery particles in microfluidic devices / J Control Release 190:139~149
Blackwell JE / 2001 / Ligand coated nanosphere adhesion to E- and P-selectin under static and flow conditions / Ann Biomed Eng 29:523~533
Blanco E / 2015 / Principles of nanoparticle design for overcoming biological barriers to drug delivery / Nat Biotechnol 33:941~951
Bodin P / 2001 / Evidence that release of adenosine triphosphate from endothelial cells during increased shear stress is vesicular / J Cardiovasc Pharmacol 38:900~908
Chachisvilis M / 2006 / G protein-coupled receptors sense fluid shear stress in endothelial cells / Proc Natl Acad Sci USA 103:15463~15468
Blackwell JE / 2001 / Ligand coated nanosphere adhesion to E- and P-selectin under static and flow conditions / Ann Biomed Eng 29:523~533
Blanco E / 2015 / Principles of nanoparticle design for overcoming biological barriers to drug delivery / Nat Biotechnol 33:941~951
Bodin P / 2001 / Evidence that release of adenosine triphosphate from endothelial cells during increased shear stress is vesicular / J Cardiovasc Pharmacol 38:900~908
Chachisvilis M / 2006 / G protein-coupled receptors sense fluid shear stress in endothelial cells / Proc Natl Acad Sci USA 103:15463~15468
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