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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제48권 제5호
- 발행연도
- 2018.9
- 수록면
- 565 - 574 (10page)
- DOI
- 10.1007/s40005-017-0350-8
이용수
초록· 키워드
오류제보하기
Plant derived natural products have been the major source for treatment of diseases traditionally but with the advent of modern systems of medicine, there is need to explore the active constituents present in it followed by modification for better therapeutic activity, low toxicity and favorable pharmacokinetics to become a drug molecule. A simple, rapid and sensitive high-performance liquid chromatography?tandem mass spectrometry (LC? MS/MS) method was developed and validated according to Food and Drug Administration guidelines for determination of IS01957, a derivative of naturally occurring para coumaric acid in mice plasma. The extraction of the analyte and the internal standard (Carbamazepine) from the plasma samples involved protein precipitation using acetonitrile.
Results of validation parameters were met with the acceptance criteria of the FDA guidelines. Method was highly sensitive (5 ng/mL) that could determine very low concentration of compound in plasma The developed and validated method was successfully applied to determine compound’s metabolic stability in mouse liver microsomes (MLM) and human liver microsomes (HLM). Test compound was found to be stable in MLM and HLM in the experimental conditions. Metabolic stability data was extrapolated which was further correlated to pharmacokinetics study in mice through oral, intraperitoneal and intravenous administration. In-vitro half life was found to be greater than 2 h in both MLM and HLM. Hepatic extraction ratio of the compound was found to be in the intermediate range. Pharmacokinetic evaluations revealed that it is a suitable candidate for intraperitoneal as well as oral administration.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Baranczewski P / 2006 / Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development / Pharmacol Rep 58:453~472
Beg S / 2011 / Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives / Pharmacogn Rev 5:120~137
Bhatta RS / 2011 / Bioanalytical method development and validation for simultaneous estimation of (R)- and (S)-isomers of S002-333: a potent novel anti-thrombotic agent using LC-MS/MS / Med Chem Res 20:1581~1588
Calixto JB / 2009 / Botanical analgesic and anti-inflammatory drugs. In: Ethnopharmacology, vol II / Eolss Publishers :36~60
Caterina MJ / 1997 / The capsaicin receptor: a heat-activated ion channel in the pain pathway / Nature 23:816~824
Beg S / 2011 / Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives / Pharmacogn Rev 5:120~137
Bhatta RS / 2011 / Bioanalytical method development and validation for simultaneous estimation of (R)- and (S)-isomers of S002-333: a potent novel anti-thrombotic agent using LC-MS/MS / Med Chem Res 20:1581~1588
Calixto JB / 2009 / Botanical analgesic and anti-inflammatory drugs. In: Ethnopharmacology, vol II / Eolss Publishers :36~60
Caterina MJ / 1997 / The capsaicin receptor: a heat-activated ion channel in the pain pathway / Nature 23:816~824
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