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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제9호
- 발행연도
- 2021.9
- 수록면
- 1,281 - 1,287 (7page)
- DOI
- 10.4014/jmb.2105.05032
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초록· 키워드
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Clinical and preclinical studies have reported that Lactobacillus gasseri BNR17, a probiotic bacterial strain isolated from human breast milk, reduces body weight and white adipose tissue volume. In order to further explore the actions of L. gasseri BNR17, we investigated the anti-menopausal effects of L. gasseri BNR17 in an ovariectomized (OVX) rat model. The serum alanine aminotransferase levels of the rats in the OVX-BNR17 group were lower than those of the rats in the OVX-vehicle only (OVXVeh) group. Upon administration of L. gasseri BNR17 after ovariectomy, calcitonin and Serotonin 2A levels increased significantly, whereas serum osteocalcin levels showed a decreasing tendency.
Compared to the rats in the OVX-Veh group, those in the OVX-BNR17 group showed lower urine deoxypyridinoline levels, lower pain sensitivity, and improved vaginal cornification. Furthermore, L. gasseri BNR17 administration increased bone mineral density in the rats with OVX-induced femoral bone loss. These results suggest that L. gasseri BNR17 administration could alleviate menopausal symptoms, indicating that this bacterium could be a good functional probiotic for managing the health of older women.
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등록된 정보가 없습니다.
참고문헌 (66)
참고문헌 신청
Davis SR / 2015 / Menopause / Nat. Rev. Dis. Primers 1:15004
Monteleone P / 2018 / Symptoms of menopause-global prevalence, physiology and implications / Nat. Rev. Endocrinol 14:199~215
Mohammadalizadeh Charandabi S / 2015 / Quality of life of postmenopausal women and their spouses : a community-based study / Iran Red. Crescent. Med. J 17:e21599
Hill K / 1996 / The demography of menopause / Maturitas 23:113~127
Rossouw JE / 2002 / Risks and benefits of estrogen plus progestin in healthy postmenopausal women : principal results From the Women's Health Initiative randomized controlled trial / JAMA 288:321~333
Monteleone P / 2018 / Symptoms of menopause-global prevalence, physiology and implications / Nat. Rev. Endocrinol 14:199~215
Mohammadalizadeh Charandabi S / 2015 / Quality of life of postmenopausal women and their spouses : a community-based study / Iran Red. Crescent. Med. J 17:e21599
Hill K / 1996 / The demography of menopause / Maturitas 23:113~127
Rossouw JE / 2002 / Risks and benefits of estrogen plus progestin in healthy postmenopausal women : principal results From the Women's Health Initiative randomized controlled trial / JAMA 288:321~333
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