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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 770 - 777 (8page)
- DOI
- 10.3349/ymj.2017.58.4.770
이용수
초록· 키워드
오류제보하기
Purpose: Tenofovir disoproxil fumarate (TDF) is commonly prescribed as a fixed-dose, co-formulated antiretroviral drug for HIV-1 infection. The major concern of long-term TDF use is renal dysfunction. However, little is known about the long-term patterns of changes in renal function in HIV-infected Koreans receiving TDF.
Materials and Methods: We prospectively followed 50 HIV-infected Koreans, performing laboratory tests every 3 months during the first year and every 6 months for the next 2 years. Urine N-acetyl-β-D-glucosaminidase (NAG) and plasma cystatin-C were measuredusing samples collected in the first year. Data on renal function were retrospectively collected on HIV-infected patients receivingfirst-line TDF (n=40) and in antiretroviral therapy (ART)-naive patients (n=24) for 3 years. Renal function was evaluated as estimated glomerular filtration rate (eGFR) from serum creatinine [Modification of Diet in Renal Disease (MDRD)] and cystatin-C.
Results: The eGFR (cystatin-C) showed significant changes from 0 to 48 wks (p=0.002), with the lowest levels at 24 wks (84.3±18.8 mL/min vs. 90.3±22.5 mL/min, p=0.021 by post hoc test). Urine NAG levels did not differ at 0, 12, 24, and 48 wks, although eGFR (MDRD) significantly decreased from 0 (98.7±18.9 mL/min/1.73 m2) to 144 wks (89.0±14.7 mL/min/1.73 m2) (p=0.010). The first-line TDF group had significantly lower eGFR (MDRD) than the ART-naive group at 144 wks (89.7 mL/min/1.73 m2 vs. 98.4 mL/min/1.73 m2, p=0.036). Thirteen (26%) participants experienced a decrease in renal impairment of 10 mL/min/1.73 m2 in eGFR (MDRD) at 144 wks.
Conclusion: These data suggest that clinically meaningful renal injury can develop in HIV-infected Koreans receiving long-term TDF.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Hemkens LG / 2015 / Comparative effectiveness of tenofovir in treatment-naïve HIV-infected patients: systematic review and meta-analysis / HIV Clin Trials 16:178~189
Prasitsuebsai W / 2016 / Treatment outcomes and resistance patterns of children and adolescents on second-line antiretroviral therapy in Asia / J Acquir Immune Defic Syndr 72:380~386
Brooks K / 2016 / Treatment failure and drug resistance in HIV-positive patients on tenofovir-based first-line antiretroviral therapy in western Kenya / J Int AIDS Soc 19:20798
Labhardt ND / 2015 / Is zidovudine first-line therapy virologically comparable to tenofovir in resource-limited settings? / Trop Med Int Health 20:914~918
Gallant JE / 2004 / Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial / JAMA 292:191~201
Prasitsuebsai W / 2016 / Treatment outcomes and resistance patterns of children and adolescents on second-line antiretroviral therapy in Asia / J Acquir Immune Defic Syndr 72:380~386
Brooks K / 2016 / Treatment failure and drug resistance in HIV-positive patients on tenofovir-based first-line antiretroviral therapy in western Kenya / J Int AIDS Soc 19:20798
Labhardt ND / 2015 / Is zidovudine first-line therapy virologically comparable to tenofovir in resource-limited settings? / Trop Med Int Health 20:914~918
Gallant JE / 2004 / Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial / JAMA 292:191~201
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