Immunological mechanism of postherpetic neuralgia and effect of pregabalin treatment on the mechanism: a prospective single-arm observational study

Aysel Mercan; Sema Tuncer Uzun; Sevgi Keles; Gulcin Hacibeyoglu; Resul Yilmaz; Ruhiye Reisli

doi:10.3344/kjp.2021.34.4.463

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자료유형: 학술저널

저자정보: Aysel Mercan (Necmettin Erbakan University Meram Faculty of Medicine) Sema Tuncer Uzun (Necmettin Erbakan University Meram Faculty of Medicine) Sevgi Keles (Necmettin Erbakan University Meram Faculty of Medicine) Gulcin Hacibeyoglu (Necmettin Erbakan University Meram Faculty of Medicine) Resul Yilmaz (Necmettin Erbakan University Meram Faculty of Medicine) Ruhiye Reisli (Necmettin Erbakan University Meram Faculty of Medicine)

저널정보: 대한통증학회 The Korean Journal of Pain The Korean Journal of Pain 제34권 제4호

발행연도: 2021.10

수록면: 463 - 470 (8page)

DOI: 10.3344/kjp.2021.34.4.463

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Background: Although neuropathic pain is a severe and common pain, its pathophysiology has not been elucidated yet. Studies in recent years have focused on the immune system’s role in the pathogenesis of neuropathic pain. The aim of this study was to investigate the role of immunological mechanisms in neuropathic pain and the effect of pregabalin by measuring immunological marker levels in peripheral blood before and after pregabalin treatment in postherpetic neuralgia (PHN) patients with neuropathic pain. Methods: Forty patients diagnosed with PHN were included in the study. CD4, T follicular cells (Tfh: CD4+CXCR5+PD1+), Th17 (CD4+CCR6+ and CD4+IL17A+), regulatory T cells (Treg: CD4+ CD25+foxp3+), Th1 (CD4+ CXCR3+ and CD4+ IFN-γ+) and Th2 (CD4+ IL-4+) cell ratios were measured in peripheral blood samples before treatment and after 3 months of treatment. Results: When immunological marker and inflammation parameter levels were compared before and after treatment, the helper T cell ratio (CD3+, CD4+) was 30.28 ± 12.27% before treatment and 34.93 ± 11.70% after treatment, so there was a statistically significant increase (P = 0.028). Th17 was 4.75 ± 5.02% before treatment and 5.80 ± 3.13% after treatment, and there was a statistically significant increase (P = 0.036). Conclusions: Immunological mechanisms play an essential role in the pathogenesis of neuropathic pain, immunologically based treatment approach will be the critical point of treatment.

#Cytokines #Immune System #Interleukin-17 #Neuralgia #Postherpetic #Pain #Pregabalin #Th17 Cells #T-Lymphocytes #Regulatory.

참고문헌 (42)

참고문헌 신청

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Tian L / 2012 / Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases / J Neuroinflammation 9:155

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