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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.4
- 수록면
- 124 - 128 (5page)
- DOI
- https://doi.org/10.3904/kjm.2020.95.2.124
이용수
초록· 키워드
오류제보하기
Atypical hemolytic uremic syndrome (aHUS) is a rare syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal injury, which results from uncontrolled complement activation. Delayed diagnosis and treatment of aHUS may result in end-stage renal disease (ESRD) and an associated dependence on dialysis. In extreme cases, it may cause death due to multi-organ failure. Eculizumab, a humanized monoclonal antibody against C5, inhibits the formation of the terminal membrane attack complex and is used to treat aHUS. Here, we report a 46-year-old male patient who suffered from aHUS relapse, despite prior treatment with repeated plasma exchange and hemodialysis. Eculizumab therapy improved his hematologic findings without use of hemodialysis.
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등록된 정보가 없습니다.
참고문헌 (7)
참고문헌 신청
정해일 / 2016 / Clinical Practice Guidelines for the Management of Atypical Hemolytic Uremic Syndrome in Korea / Journal of Korean Medical Science 31(10):1516~1528
Noris M / 2009 / Atypical hemolytic-uremic syndrome / N Eng J Med 361:1676~1687
Gordjani N / 1997 / Hemolytic uremic syndromes in childhood / Semin Thromb Hemost 23:281~293
Noris M / 2014 / Dynamics of complement activation in aHUS and how to monitor eculizumab therapy / Blood 124:1715~1726
Kavanach D / 2013 / Atypical hemolytic uremic syndrome / Semin Nephrol 33:508~530
Noris M / 2009 / Atypical hemolytic-uremic syndrome / N Eng J Med 361:1676~1687
Gordjani N / 1997 / Hemolytic uremic syndromes in childhood / Semin Thromb Hemost 23:281~293
Noris M / 2014 / Dynamics of complement activation in aHUS and how to monitor eculizumab therapy / Blood 124:1715~1726
Kavanach D / 2013 / Atypical hemolytic uremic syndrome / Semin Nephrol 33:508~530
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