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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제2호
- 발행연도
- 2018.3
- 수록면
- 163 - 172 (10page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.2.163
이용수
초록· 키워드
오류제보하기
PRF001 is a fragmented DNA polymer extracted from the testes of salmon.
The purpose of this study was to assess the anti-inflammatory effect of PRF001 in vitro as well as the protective effect of PRF001 intake against arthritis in a rat model.
In vitro, cell survival and inflammatory markers after H2O2 treatment to induce cell damage were investigated in CHON-001 cells treated with different concentrations of PRF001. In vivo, osteoarthritis was induced by intra-articular injection of monosodium iodoacetate (MIA) into the knee joints of rats. After consumption of PRF001 (10, 50, or 100 mg/kg) for 4 weeks, inflammatory mediators and cytokines in articular cartilage were investigated. In vitro, the levels of inflammatory markers, IL-1β, TNF-α, COX-2, iNOS, and PGE2, were significantly suppressed by PRF001 treatment. In vivo, the inflammatory mediators and cytokines, IL-1β, p- Erk1/2, NF-kB, TNF-α, COX-2, and PGE2, as well as MMP3 and MMP7, which have catabolic activity in chondrocytes, were decreased in the MIA-induced osteoarthritic rats following intake of PRF001.
Histological analysis revealed that PRF001 had a protective effect on the articular cartilage.
Altogether, these results demonstrated that the anti-inflammatory property of PRF001 contributes to its protective effects in osteoarthritis through deregulating IL- 1β, TNF-α, and subsequent signals, such as p-Erk1/2, NF-κB, COX-2, PGE2, and MMPs.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Johnston SA. Osteoarthritis / 1997 / Joint anatomy, physiology, and pathobiology / Vet Clin North Am Small Anim Pract 27:699~723
Altman R / 1986 / Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association / Arthritis Rheum 29:1039~1049
Wearing SC / 2006 / Musculoskeletal disorders associated with obesity: a biomechanical perspective / Obes Rev 7:239~250
Campo GM / 2009 / Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes / J Cell Biochem 106:83~92
Herrington C / 2008 / Molecular and cellular themes in inflammation and immunology / J Pathol 214:123~125
Altman R / 1986 / Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association / Arthritis Rheum 29:1039~1049
Wearing SC / 2006 / Musculoskeletal disorders associated with obesity: a biomechanical perspective / Obes Rev 7:239~250
Campo GM / 2009 / Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes / J Cell Biochem 106:83~92
Herrington C / 2008 / Molecular and cellular themes in inflammation and immunology / J Pathol 214:123~125
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