개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 712 - 723 (12page)
- DOI
- 10.23876/j.krcp.21.080
이용수
초록· 키워드
오류제보하기
Background: Anti-heparin/platelet factor 4 (PF4) antibodies may trigger severe thrombotic complications in hemodialysis (HD) pa- tients. Tetrameric PF4 has a high affinity for extracellular DNA, which is a key component of neutrophil extracellular traps (NETs); therefore, the interactions between anti-heparin/PF4 antibodies and NETs can contribute to prothrombotic events.
Methods: Anti-heparin/PF4 antibody levels were measured by enzyme-linked immunosorbent assay and an optical density > 1.8 was regarded as clinically significant. We additionally measured serum nucleosome levels as representative markers of NETs, and the contributions of anti-heparin/PF4 and increased serum nucleosome levels to the primary functional patency loss of vascular access was assessed.
Results: The frequency of anti-heparin/PF4 antibodies was significantly higher in incident HD patients compared to prevalent HD pa- tients (23.6% vs. 7.7%). Serum nucleosome levels, as well as the white blood cell counts, neutrophil counts, and high- sensitivity C-re- active protein levels, were significantly higher in anti-heparin/PF4 antibody-positive patients compared to the control. Platelet counts tended to be lower in the patients with anti-heparin/PF4 of >1.8 than in the controls. Relative risk calculations showed that the pres- ence of anti-heparin/PF4 antibodies increased the risk of primary functional patency failure by 4.28-fold, and this risk increased fur- ther with higher nucleosome levels. Furthermore, in the anti-heparin/PF4 antibody-positive group, the time to first vascular interven- tion was much shorter, and the risk of repeated intervention was higher, compared to the controls.
Conclusion: In incident HD patients, the presence of anti-heparin/PF4 antibodies was associated with increased NET formation; this could be a strong predictor of vascular access complications
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Monroy-Cuadros M / 2010 / Risk factors associated with patency loss of hemodialysis vascular access within 6 months / Clin J Am Soc Nephrol 5:1787~1792
Warkentin TE / 2000 / Impact of the patient population on the risk for heparin-induced thrombocytopenia / Blood 96:1703~1708
Kato S / 2011 / Heparin-induced throm"bocytopenia : analysis of risk factors in medical inpatients / Br J Haematol 154:373~377
Nand S / 1997 / Heparin-induced thrombocytopenia with thrombosis : inci"dence, analysis of risk factors, and clinical outcomes in 108 consecutive patients treated at a single institution / Am J Hematol 56:12~16
Rauova L / 2006 / Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis : diagnostic and therapeutic implications / Blood 107:2346~2353
Warkentin TE / 2000 / Impact of the patient population on the risk for heparin-induced thrombocytopenia / Blood 96:1703~1708
Kato S / 2011 / Heparin-induced throm"bocytopenia : analysis of risk factors in medical inpatients / Br J Haematol 154:373~377
Nand S / 1997 / Heparin-induced thrombocytopenia with thrombosis : inci"dence, analysis of risk factors, and clinical outcomes in 108 consecutive patients treated at a single institution / Am J Hematol 56:12~16
Rauova L / 2006 / Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis : diagnostic and therapeutic implications / Blood 107:2346~2353
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